{"created":"2023-07-27T06:55:03.951073+00:00","id":50724,"links":{},"metadata":{"_buckets":{"deposit":"c1a78f80-f201-4a0c-b4c9-4e4128e94181"},"_deposit":{"created_by":18,"id":"50724","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50724"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050724","sets":["2812:2813:2823"]},"author_link":["91848","274"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2008-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ヒト慢性骨髄性白血病(Chronic myeloid leukemia;CML)の治療にはチロシンキナーゼ阻害剤イマチニブが広く用いられているが,イマチニブ抵抗性の白血病幹細胞の残存はCMLの再発を引き起す原因となる.本研究では,CMLマウスモデルより純化した白血病幹細胞を用いて,TGF-・-FOXOシグナルが白血病幹細胞の維持,並びにイマチニブ抵抗性の制御に関わっていることを解明した.さらに,TGF-・阻害薬がイマチニブ抵抗性の白血病幹細胞に対して治療効果を有していることを発見した.","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we demonstrated a critical role for the TGF-β-FOXO pathway in maintenance and imatinib resistance of leukemia-initiating cells (LICs) in chronic myeloid leukemia (CML) which are responsible for recurrence of disease. TGF-β inhibitor in combination with imatinib treatment led to efficient depletion of LICs in vivo.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「フォークヘッド転写因子Foxoによる白血病幹細胞の維持機構の解明」課題番号20590394\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20590394/20590394seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057032","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん研究所"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70372688"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70372688","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590394/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590394/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20590394/20590394seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20590394/20590394seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-14"}],"displaytype":"detail","filename":"CA-PR-NAKA-K-kaken 2011-6p.pdf","filesize":[{"value":"195.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-NAKA-K-kaken 2011-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50724/files/CA-PR-NAKA-K-kaken 2011-6p.pdf"},"version_id":"8a972d15-cc91-4955-a718-72c67b6df87a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"フォークヘッド転写因子Foxoによる白血病幹細胞の維持機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"フォークヘッド転写因子Foxoによる白血病幹細胞の維持機構の解明"},{"subitem_title":"Molecular mechanisms maintaining leukemic stem cells by forkhead transcription factor Foxo","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-02-14"},"publish_date":"2020-02-14","publish_status":"0","recid":"50724","relation_version_is_last":true,"title":["フォークヘッド転写因子Foxoによる白血病幹細胞の維持機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:22:01.172887+00:00"}