{"created":"2023-07-27T06:55:03.995989+00:00","id":50725,"links":{},"metadata":{"_buckets":{"deposit":"4dcb0965-c892-4055-85c3-a0076bce150d"},"_deposit":{"created_by":18,"id":"50725","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50725"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050725","sets":["2812:2813:2822"]},"author_link":["24839","91837"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-19","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2009-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"(1)ある種のγ-セクレターゼ阻害剤が、γ-セクレターゼ活性の阻害以外の機序によってRAGEシグナリングを抑制することが示された。(2) cAMPがMMP9の活性化を介して、膜型RAGEのシェディングを促進し、膜型RAGEの減少による効果と、遊離された細胞外ドメインのおとり受容体としての効果の両者によって、RAGEシグナルを抑制することを明らかにした。(3) cAMPシグナルを増強するPDE阻害剤のRAGE関連疾患に対する治療薬としての可能性を、マウスの腸疾患モデルを用いて検討し、当該薬剤が病態の進行を抑制する可能性が示された。","subitem_description_type":"Abstract"},{"subitem_description":"(1) We found a gamma-secretase inhibitor suppressed RAGE signaling by unknown mechanism other than inhibition of gamma-secretase activity.(2) We clarified that the cAMP exerts the inhibitory effects on RAGE signaling by enhancement of MMP9-mediated RAGE shedding that leads to decrease of membrane-bound form RAGE and increase of decoy/soluble form RAGE.(3) We showed the possibility that the PDE inhibitor, which cause enforcement of cAMP signaling could suppress the inflammatory bowel disease using mouse model.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21590304, 研究期間(年度):2009-2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「RAGEオリゴマー化とγ-セクレターゼによる新たなシグナル受容機構の解明」課題番号21590304\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21590304/21590304seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057033","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40303268"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40303268","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590304/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590304/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21590304/21590304seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21590304/21590304seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-14"}],"displaytype":"detail","filename":"ME-PR-WATANABE-T-kaken 2012-5p.pdf","filesize":[{"value":"192.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-WATANABE-T-kaken 2012-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50725/files/ME-PR-WATANABE-T-kaken 2012-5p.pdf"},"version_id":"b8e330fd-52a8-44fa-a1ba-9822a6956795"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"RAGEオリゴマー化とγ-セクレターゼによる新たなシグナル受容機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"RAGEオリゴマー化とγ-セクレターゼによる新たなシグナル受容機構の解明"},{"subitem_title":"A novel signal reception mechanism by oligomerization of RAGE and gamma-secretase","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-02-14"},"publish_date":"2020-02-14","publish_status":"0","recid":"50725","relation_version_is_last":true,"title":["RAGEオリゴマー化とγ-セクレターゼによる新たなシグナル受容機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:24:58.625853+00:00"}