{"created":"2023-07-27T06:55:06.443038+00:00","id":50789,"links":{},"metadata":{"_buckets":{"deposit":"feacf795-1895-4571-892f-41235f3f640e"},"_deposit":{"created_by":18,"id":"50789","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50789"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050789","sets":["2812:2813:2819"]},"author_link":["85518","40"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-06-03","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2012-04-01 - 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、薬剤評価に用いるヒト培養細胞の遺伝子発現レベルをデータベース化し、癌細胞に高発現している機能性分子を予め探索するとともに、ヒト腫瘍培養細胞で高発現を確認した機能性分子安定発現系を分子プローブのスクリーニングに利用して、ポストFDG製剤の有力候補である標識アミノ酸製剤のアミノ酸トランスポータ及び薬物トランスポータに対する親和性を詳細に検討し、アミノ酸トランスポータ遺伝子発現と腫瘍集積性との相関からその設計戦略の妥当性を検証した。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, while searching this research for the functional biomolecule used by the database for the gene expression level in the human cultured cells for evaluation of imaging probes, as well as human tumor culturing cells in a stable functional molecule was confirmed with high expression by using the expression system for the screening of molecular probes, the labeled amino acid derivatives are especially taken up also in a post-FDG candidate probe, and the accumulation mechanism of the labeled amino acids which shows high affinity to the amino acid transporters to which high revelation is specifically accepted by a tumor was examined in detail, and the validity of the design strategy was evaluated from correlation with amino acid transporter gene expression and tumor accumulation of the probes.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24659558, 研究期間(年度):2012-04-01 - 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「細胞の遺伝子発現解析に基づく機能性分子発現系を利用した腫瘍診断薬の設計戦略の検証」課題番号24659558\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24659558/24659558seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057097","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域保健学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30204663"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30204663","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24659558/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24659558/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24659558/24659558seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24659558/24659558seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-20"}],"displaytype":"detail","filename":"ME-PR-KAWAI-K-kaken 2015-6p.pdf","filesize":[{"value":"298.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KAWAI-K-kaken 2015-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50789/files/ME-PR-KAWAI-K-kaken 2015-6p.pdf"},"version_id":"ed766c5c-b702-43b7-a0ad-27e5178b2513"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"細胞の遺伝子発現解析に基づく機能性分子発現系を利用した腫瘍診断薬の設計戦略の検証","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"細胞の遺伝子発現解析に基づく機能性分子発現系を利用した腫瘍診断薬の設計戦略の検証"},{"subitem_title":"The design strategy for tumor diagnostic agents utilizing the functional biomolecule expression system based on gene expression analysis of tumor cells","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-02-20"},"publish_date":"2020-02-20","publish_status":"0","recid":"50789","relation_version_is_last":true,"title":["細胞の遺伝子発現解析に基づく機能性分子発現系を利用した腫瘍診断薬の設計戦略の検証"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:52:01.319443+00:00"}