{"created":"2023-07-27T06:55:06.487734+00:00","id":50790,"links":{},"metadata":{"_buckets":{"deposit":"2f055808-4d46-4948-be66-8cc935fb0793"},"_deposit":{"created_by":18,"id":"50790","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50790"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050790","sets":["2812:2813:2822"]},"author_link":["85518","40"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-15","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2009-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、薬剤評価に用いるヒト培養細胞の遺伝子発現レベルをデータベース化し、癌細胞に高発現している機能性分子を予め探索するとともに、特にポストFDG製剤の中でも有力候補であるアミノ酸製剤を取り上げ、腫瘍で特異的に高発現が認められるアミノ酸トランスポータに高親和性を示す標識アミノ酸の集積機序を詳細に検討し、アミノ酸トランスポータ遺伝子発現と腫瘍集積性との相関からその設計戦略の妥当性を評価した。","subitem_description_type":"Abstract"},{"subitem_description":"While searching this research for the functional biomolecule used by the database for the gene expression level of the human cultured cells for evaluation of imaging probes, and it has high-expressed to the tumor cell beforehand, the amino acid derivatives are especially taken up also in a post-FDG candidate probe, and the accumulation mechanism of the labeled amino acids which shows high affinity to the amino acid transporters to which high revelation is specifically accepted by a tumor was examined in detail, and the validity of the design strategy was evaluated from correlation with amino acid transporter gene expression and tumor accumulation of the probes.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21659286, 研究期間(年度):2009-2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ヒト培養細胞の機能性分子発現解析に基づくポストFDG腫瘍診断薬の設計戦略の構築」課題番号21659286\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21659286/21659286seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057098","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域保健学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30204663"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30204663","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21659286/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21659286/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21659286/21659286seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21659286/21659286seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-20"}],"displaytype":"detail","filename":"ME-PR-KAWAI-K-kaken 2012-5p.pdf","filesize":[{"value":"269.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KAWAI-K-kaken 2012-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50790/files/ME-PR-KAWAI-K-kaken 2012-5p.pdf"},"version_id":"8c62e422-6616-4e6b-b7d3-001276a2ca6b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ヒト培養細胞の機能性分子発現解析に基づくポストFDG腫瘍診断薬の設計戦略の構築","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト培養細胞の機能性分子発現解析に基づくポストFDG腫瘍診断薬の設計戦略の構築"},{"subitem_title":"The probe design strategy of post-FDG tumor diagnostic agents based on the functional biomolecule expression analysis of human cultured cells","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-02-20"},"publish_date":"2020-02-20","publish_status":"0","recid":"50790","relation_version_is_last":true,"title":["ヒト培養細胞の機能性分子発現解析に基づくポストFDG腫瘍診断薬の設計戦略の構築"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:25:01.635667+00:00"}