{"created":"2023-07-27T06:55:06.532011+00:00","id":50791,"links":{},"metadata":{"_buckets":{"deposit":"b098b851-5efa-45b1-ab64-0742134db728"},"_deposit":{"created_by":18,"id":"50791","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"50791"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00050791","sets":["2812:2813:2822"]},"author_link":["85518","40"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-15","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2008-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 基盤研究(A) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"再生医療効果判定への応用の観点から、パーキンソン病モデルラットの破壊側線条体に胎仔中脳ドーパミン神経細胞を移植した移植群を用いて、ドーパミン神経機能に関連するPET製剤投与により解析した結果、個体差は大きかったものの、行動薬理試験および免疫染色による機能回復に一定の効果が得られた。さらに、薬物投与モデルラットを用いた神経機能変化の評価も実施し、疾患部位における神経機能に関連する機能性分子の遺伝子発現レベルを網羅的に解析するとともに、移植や薬物投与後の神経機能変化と比較検討した。","subitem_description_type":"Abstract"},{"subitem_description":"As a result of analyzing by PET tracers relevant to function analysis of cerebral dopaminergic neuron using the transplant group which was transplanted the rat intrastriatal grafts of fetal ventral mesencephalon of a Parkinson's disease model rat aiming at the diagnostic application to the regeneration effect of medicine, the individual specificity in a transplant group was large, but the significant correlation was acquired between the functional recovery by the degree of methamphetamine-induced rotation test and immunity dyeing analysis. Furthermore, functional change of cerebral dopaminergic neuron in a psychiatry drug administration model rat was also evaluated, the gene expression level of the functional molecule relevant to the nervous function in the pathological part after a transplant or drug administration was analyzed comprehensively, and comparison examination was carried out with functional change of cerebral dopaminergic neuron.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:20249055, 研究期間(年度):2008-2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「脳内神経変性疾患に対する再生医療・遺伝子治療効果判定に有用な放射性診断薬の開発」課題番号20249055\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20249055/20249055seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057099","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域保健学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30204663"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30204663","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20249055/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20249055/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20249055/20249055seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20249055/20249055seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-20"}],"displaytype":"detail","filename":"ME-PR-KAWAI-K-kaken 2012A-5p.pdf","filesize":[{"value":"289.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KAWAI-K-kaken 2012A-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/50791/files/ME-PR-KAWAI-K-kaken 2012A-5p.pdf"},"version_id":"438fbd4f-e761-4977-817a-9aac60e718a1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"脳内神経変性疾患に対する再生医療・遺伝子治療効果判定に有用な放射性診断薬の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脳内神経変性疾患に対する再生医療・遺伝子治療効果判定に有用な放射性診断薬の開発"},{"subitem_title":"Development of novel radiopharmaceuticals for diagnosis of cerebral neurodegeneration and functional recovery after intrastriatal grafts / gene therapy","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-02-20"},"publish_date":"2020-02-20","publish_status":"0","recid":"50791","relation_version_is_last":true,"title":["脳内神経変性疾患に対する再生医療・遺伝子治療効果判定に有用な放射性診断薬の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:25:04.216676+00:00"}