{"created":"2023-07-27T06:55:19.189542+00:00","id":51111,"links":{},"metadata":{"_buckets":{"deposit":"71c73cfb-e236-4886-86d1-c481ee4a27a7"},"_deposit":{"created_by":18,"id":"51111","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51111"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051111","sets":["2812:2813:3929"]},"author_link":["31","78713"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-27","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"13p.","bibliographicVolumeNumber":"2017-04-01 - 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では免疫系に情報伝達する胚シグナルとして透明帯、HCGおよびlaeverinに焦点をあて、その作用機序を解析した。その結果、免疫反応を誘起するHCGと透明帯蛋白のペプチド構造が推定でき、またr-laeverin とlaeverin発現細胞を作成して免疫細胞に対するlaeverinの作用が確認できた。さらに標識-r-laeverin を用いてlaeverinと結合する蛋白（受容体の候補分子）を胎盤から分離・精製し、これを同定することに成功した。一方で上記の知見をもとに胚シグナルによる免疫細胞の反応assay系の確立をすすめ、着床不全患者に対するスクリーニング法を開発する可能性が示された。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we examined the molecular mechanisms of embryonic signals, such as zona pellucida, HCG, and laeverin, which induce functional changes in the immune system. We identified the candidates of peptide-structures for embryonic signals from zona pellucida and HCG, and also confirmed the significant effects of laeverin on immune cells using r-laeverin and laeverin-overexpressing cell lines. We further identified a candidate for laeverin receptor by analyzing the proteins purified from placenta using labeled-r-laeverin. In addition, based on the above findings, we established an assay system to evaluate responsibility of immune cells against embryonic signals, which will contribute to developing a screening test for patients suffering from repeated implantation failure.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17H04337, 研究期間(年度):2017-04-01 - 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「免疫系を介した胚着床誘導機構の解明: 胚シグナルの同定と機能解析」研究成果報告書　課題番号17H04337\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17H04337/17H04337seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057414","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30252456"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30252456","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04337/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04337/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17H04337/17H04337seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17H04337/17H04337seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-16"}],"displaytype":"detail","filename":"ME-PR-FUJIWARA-H-kaken 2020-13p.pdf","filesize":[{"value":"100.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-FUJIWARA-H-kaken 2020-13p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51111/files/ME-PR-FUJIWARA-H-kaken 2020-13p.pdf"},"version_id":"e7d36771-3ade-40d3-b17c-ec0c21bf71e9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"免疫系を介した胚着床誘導機構の解明: 胚シグナルの同定と機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"免疫系を介した胚着床誘導機構の解明: 胚シグナルの同定と機能解析"},{"subitem_title":"Promoting mechnisms of embryonic signals in embryo implantation induced by the immune system","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-16"},"publish_date":"2021-04-16","publish_status":"0","recid":"51111","relation_version_is_last":true,"title":["免疫系を介した胚着床誘導機構の解明: 胚シグナルの同定と機能解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:02:25.104919+00:00"}