{"created":"2023-07-27T06:55:19.326487+00:00","id":51114,"links":{},"metadata":{"_buckets":{"deposit":"f8183080-3bf7-468d-ac6d-0b7dbd4e20e9"},"_deposit":{"created_by":18,"id":"51114","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51114"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051114","sets":["2812:2813:4014"]},"author_link":["2343","20177"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-04-12","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"14p.","bibliographicVolumeNumber":"2017-04-01 - 2021-03-31","bibliographic_titles":[{"bibliographic_title":"令和2(2020)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2020 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、上咽頭癌・中咽頭癌いずれにおいても細胞老化現象と癌化・転移の関連性は示されなかった。両者でミトコンドリアDNAで様々な変異を認め、特に上咽頭癌では転移との関連性が明らかになった。上咽頭癌ではミトコンドリアDNAの変異は主にシチジンデアミナーゼによるもので、一方、中咽頭癌ではシチジンデアミナーゼによるものと活性酸素種によるものが混在していた。\n以上の成果により、ミトコンドリアDNAの変異によって転移が促進される現象の存在が示された。そして今後、ミトコンドリアDNAと転移を結びつけるメカニズムの解明が求められる。","subitem_description_type":"Abstract"},{"subitem_description":"In the current study, we cannot find any correlated biological background between senescence-associated secretory phenotype (SASP), and cancerization and metastatic potential in both nasopharyngeal carcinoma (NPC) and oropharyngeal carcinoma (OPC). In both carcinomas, especially in NPC, mitochondrial DNA mutations were strongly correlated with metastatic potential of NPCs. We found many mitochondrial DNA mutations were due to the effect ofcytidine deaminases (CDAs) in NPC. On the other hands, the mutations were caused both by CDAs and reactive oxigen species in OPCs.\nFor the above-mentioned result, the existence of the phenomenon that metastasis was promoted by the mutatiions of the mitochondrial DNA was suggested. And an elucidation of the mechanisms to relate metastasis to mitochondrial DNA mutations is needed in the future study.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17H04343, 研究期間(年度):2017-04-01 - 2021-03-31","subitem_description_type":"Other"},{"subitem_description":"出典:「Epstein-Barrウイルスによる細胞老化関連分泌形質誘導機構の解明」研究成果報告書 課題番号17H04343\n(KAKEN:科学研究費助成事業データベース(国立情報学研究所)) \n(https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17H04343/17H04343seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057417","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70377414"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70377414","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04343/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04343/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17H04343/17H04343seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17H04343/17H04343seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-04"}],"displaytype":"detail","filename":"ME-PR-WAKISAKA-N-kaken 2021-14p.pdf","filesize":[{"value":"100.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-WAKISAKA-N-kaken 2021-14p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51114/files/ME-PR-WAKISAKA-N-kaken 2021-14p.pdf"},"version_id":"30d53a08-ae33-48a4-ab0a-07857c99ebc1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"Epstein-Barrウイルスによる細胞老化関連分泌形質誘導機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Epstein-Barrウイルスによる細胞老化関連分泌形質誘導機構の解明"},{"subitem_title":"Elucidating the mechanism for induction of senescence-associated secretory phenotype by Epstein-Barr virus","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4014"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-04"},"publish_date":"2022-02-04","publish_status":"0","recid":"51114","relation_version_is_last":true,"title":["Epstein-Barrウイルスによる細胞老化関連分泌形質誘導機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:52:39.566687+00:00"}