{"created":"2023-07-27T06:55:19.505643+00:00","id":51118,"links":{},"metadata":{"_buckets":{"deposit":"64d82ddb-c209-485e-9f80-9f75e81564ec"},"_deposit":{"created_by":18,"id":"51118","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51118"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051118","sets":["2812:2813:3929"]},"author_link":["72150","319"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-13","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"7p.","bibliographicVolumeNumber":"2017-2019","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 国際共同研究加速基金研究(国際共同研究強化) 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、がんの内用放射線治療薬[131I]MIBGの治療効果向上を目指し、[131I]MIBGの治療効果予測法と、[131I]MIBGのがん細胞外排泄阻害剤の併用投与によるがん治療効果増強法の開発を目的とした。米国内研究施設との共同研究により、[131I]MIBGの治療対象であるヒト由来神経芽細胞腫細胞株SK-N-SHにおいて、[131I]MIBGはSK-N-SHに発現する排泄型薬物トランスポータMRP1と4からがん細胞外に排泄されていた。また、MRP特異的阻害剤MK-571やprobenecidを使用し、[131I]MIBGをがん細胞内に多く滞留させるがん治療効果増強法を開発できた。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we aimed to improve the therapeutic effect of [131I] MIBG, an internal radiotherapy with radiopharmaceuticals for cancer, by using a method for predicting the therapeutic effect of [131I] MIBG and develop the cancer therapy enhancement method with combination of [131I] MIBG and the specific inhibitors for efflux transporter from cancer cells.In international collaborators in the United States, [131I] MIBG was excreted outside cancer cells via MRP1 and MRP4 in human-derived neuroblastoma cell line SK-N-SH, which is the target of treatment of [131I] MIBG. cancer cells. In addition, we have developed the cancer therapy enhancement method by using MRP-specific inhibitor MK-571 and probenecid to retain [131I] MIBG in cancer cells.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16KK0200, 研究期間(年度):2017-2019","subitem_description_type":"Other"},{"subitem_description":"出典：「高精度多剤耐性予測法に基づく内用放射線治療の効果予測法とがん治療効果増強法の開発 (国際共同研究強化)」研究成果報告書　課題番号16KK0200\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16KK0200/16KK0200seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域保健学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057421","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30444235"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30444235","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16KK0200/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16KK0200/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16KK0200/16KK0200seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16KK0200/16KK0200seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-16"}],"displaytype":"detail","filename":"ME-PR-KOBAYASHI-M-kaken 2020-7p.pdf","filesize":[{"value":"299.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KOBAYASHI-M-kaken 2020-7p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51118/files/ME-PR-KOBAYASHI-M-kaken 2020-7p.pdf"},"version_id":"45514f7b-d152-46bd-9aa0-8d892b505745"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"高精度多剤耐性予測法に基づく内用放射線治療の効果予測法とがん治療効果増強法の開発 (国際共同研究強化)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"高精度多剤耐性予測法に基づく内用放射線治療の効果予測法とがん治療効果増強法の開発 (国際共同研究強化)"},{"subitem_title":"Development of therapeutic effect prediction method and cancer therapy enhancement method for internal radiation therapy (Fostering Joint International Research)","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-16"},"publish_date":"2021-04-16","publish_status":"0","recid":"51118","relation_version_is_last":true,"title":["高精度多剤耐性予測法に基づく内用放射線治療の効果予測法とがん治療効果増強法の開発 (国際共同研究強化)"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:02:21.872509+00:00"}