{"created":"2023-07-27T06:55:19.639678+00:00","id":51122,"links":{},"metadata":{"_buckets":{"deposit":"f92e141f-64a8-48cd-82d3-3c1ce26120d4"},"_deposit":{"created_by":18,"id":"51122","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51122"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051122","sets":["2812:2813:4014"]},"author_link":["86506","86507"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-06-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"11p.","bibliographicVolumeNumber":"2017-04-01 - 2021-03-31","bibliographic_titles":[{"bibliographic_title":"令和2(2020)年度 科学研究費補助金 若手研究(A) 研究成果報告書"},{"bibliographic_title":"2020 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では，内耳の感覚細胞に発現するタンパク質モーター“プレスチン（prestin）”に着目し，その構造と機能を自在に制御する技術とこれを捉える計測技術の開発に取り組み，音受容メカニズムの解明と新規バイオデバイスの創生を目指した．タグと呼ばれる目印を付加したプレスチンを安定に発現する培養細胞株を構築した．同細胞株よりプレスチン分子を一つずつ引き抜き力-進展曲線を取得することで，プレスチンの膜内構造を解析することに成功した．","subitem_description_type":"Abstract"},{"subitem_description":"In the present study, we focused on the motor protein “prestin” expressed in the sensory cells in the inner ear. A method to handle its structure and function and a measurement technique to detect them were investigated to elucidate the mechanisms of sound perception and to develop new biodevices. Mammalian cell lines which stably express prestin with a marker peptide tag were constructed and a prestin molecule was pulled out from the plasma membrane of these cells. The force-extension curves obtained demonstrated the membrane structure of prestin.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17H04739, 研究期間(年度):2017-04-01 - 2021-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「内耳増幅の超分子メカニズム解明を目指した膜タンパク質操作・計測技術と新機能の創生」研究成果報告書　課題番号17H04739\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17H04739/17H04739seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057425","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学理工研究域フロンティア工学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70570901"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70570901","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04739/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04739/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17H04739/17H04739seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17H04739/17H04739seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-10"}],"displaytype":"detail","filename":"TE-PR-MURAKOSHI-M-kaken 2021-11p.pdf","filesize":[{"value":"866.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"TE-PR-MURAKOSHI-M-kaken 2021-11p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51122/files/TE-PR-MURAKOSHI-M-kaken 2021-11p.pdf"},"version_id":"3fb81ee3-1bc4-44b6-b870-c20a3f82c8c1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"内耳増幅の超分子メカニズム解明を目指した膜タンパク質操作・計測技術と新機能の創生","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"内耳増幅の超分子メカニズム解明を目指した膜タンパク質操作・計測技術と新機能の創生"},{"subitem_title":"Development of membrane-protein handling and measurement techniques for elucidation of supramolecular mechanisms of inner ear amplification","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4014"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-10"},"publish_date":"2022-02-10","publish_status":"0","recid":"51122","relation_version_is_last":true,"title":["内耳増幅の超分子メカニズム解明を目指した膜タンパク質操作・計測技術と新機能の創生"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:51:52.745227+00:00"}