{"created":"2023-07-27T06:55:19.729675+00:00","id":51124,"links":{},"metadata":{"_buckets":{"deposit":"5166ff0e-f81f-4f27-b315-90bd742a22cc"},"_deposit":{"created_by":18,"id":"51124","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51124"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051124","sets":["2812:2813:4085"]},"author_link":["2881","20436"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-06-07","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2019-04-01 - 2022-03-31","bibliographic_titles":[{"bibliographic_title":"令和3(2021)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2021 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Neonatal hemochromatosis is a fatal disease of fetus and infants with severe liver injury and systemic iron deposition. There is indirect evidence that maternally-derived antibody against fetal organ is responsible for the disease, although the exact antigen has not been determined to date.\nIn this study, protein-active array method was utilized to find candidate antigens of NH. Several proteins have been found as a possible target for the NH allo-reactive antibody. These targets are among proteins expressed specifically within fetal liver tissue. Further study is undergoing to prove the specificity of this antigen and to clarify the direct relationship between NH pathology and antibody directed against these antigens.","subitem_description_type":"Abstract"},{"subitem_description":"新生児ヘモクロマトーシスは胎児期に発症、生直後から高度の肝機能不全、全身臓器の鉄沈着を伴う、致死的疾患である。その原因は、胎盤を介し移行する胎児組織（アロ抗原）に反応する母体由来の抗体と考えられている。しかし、その標的となる胎児抗原は同定されておらず、診断や病態評価の指標も存在しない。\n本研究では、プロテインアクティブアレイと呼ばれる革新的な手法により、複数の症例で共通にアロ抗体を検出することが可能となった。さらに、別の方法で、胎児肝特異的に発現している複数の蛋白を同定、この中に上記の候補抗原も含まれることを確認した。\n今後は、アロ抗原と病態との関連についてさらに研究を進める。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19K08339, 研究期間(年度):2019-04-01 - 2022-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「新生児ヘモクロマトーシスの原因となるアロ抗体の同定と病態発症機序の解明」課題番号19K08339\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K08339/19K08339seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057427","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院医療安全管理部"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40210281"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40210281","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K08339/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K08339/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K08339/19K08339seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K08339/19K08339seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-02"}],"displaytype":"detail","filename":"HO-PR-YACHIE-A-kaken 2022-5p.pdf","filesize":[{"value":"77.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-YACHIE-A-kaken 2022-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51124/files/HO-PR-YACHIE-A-kaken 2022-5p.pdf"},"version_id":"0b5d8b5d-1215-4f83-b7b3-61a57561a5d7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"新生児ヘモクロマトーシスの原因となるアロ抗体の同定と病態発症機序の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新生児ヘモクロマトーシスの原因となるアロ抗体の同定と病態発症機序の解明"},{"subitem_title":"Identification of allo-specific antibody responsible for the pathogenesis of neonatal hemochromatosis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4085"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-02-02"},"publish_date":"2023-02-02","publish_status":"0","recid":"51124","relation_version_is_last":true,"title":["新生児ヘモクロマトーシスの原因となるアロ抗体の同定と病態発症機序の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:40:06.238616+00:00"}