{"created":"2023-07-27T06:55:20.140554+00:00","id":51135,"links":{},"metadata":{"_buckets":{"deposit":"bda4940b-345d-455e-80b2-b700c409ec90"},"_deposit":{"created_by":18,"id":"51135","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51135"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051135","sets":["2812:2813:4014"]},"author_link":["450","76148"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-05-02","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2018-04-01 - 2021-03-31","bibliographic_titles":[{"bibliographic_title":"令和2(2020)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2020 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"全身性強皮症、多発性筋炎/皮膚筋炎で検出される自己抗体について、Line blot法と免疫沈降法との一致率は、カットオフ値の設定によらず高確率で一致するグループ、カットオフ値の設定により一致率が向上するグループ、カットオフ値の設定によらず一致率が低い群に分類された。したがって、Line blot法の結果を解釈する際には、これらの特性を考慮に入れる必要があると考えられた。全身性強皮症関連自己抗体陰性群の臨床的特徴について検討したところ、自己抗体陰性群の臨床的特徴は抗トポイソメラーゼⅠ抗体陽性群に類似しており、自己抗体陰性群は特徴的なサブグループを形成していることが明らかになった。","subitem_description_type":"Abstract"},{"subitem_description":"We evaluated the performance of a commercial line blot (LB) assay in comparison with immunoprecipitation (IP) assays. When a cut-off was adjusted to reconcile with the results of IP assays, the detection performance of LB assay was improved for anti-EJ, anti-PL-7, anti-PL-12, anti-SRP, anti-topoisomerase I and anti-RNA polymerase III antibodies (Abs). However, the results of anti-Mi-2, anti-U3 RNP, anti-Th/To, anti-hUBF and anti-Ku Abs remained discordant between the LB assay and IP assays at all cut-off levels. Therefore, detection of autoAbs using a commercial LB assay requires great caution. We examined the clinical features of systemic sclerosis (SSc) patients negative for SSc-related autoAbs. Clinical features between patients negative for SSc-related autoAbs and those with anti-topoisomerase I Abs were similar. Therefore, patients negative for SSc-related autoAbs form a clinically distinct subset among SSc patients.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18K08266, 研究期間(年度):2018-04-01 - 2021-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「免疫沈降法による膠原病患者血清中の自己抗体の同定と臨床的特徴の検討」研究成果報告書　課題番号18K08266\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K08266/18K08266seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057438","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60420329"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60420329","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K08266/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K08266/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K08266/18K08266seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K08266/18K08266seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-04"}],"displaytype":"detail","filename":"ME-PR-HAMAGUCHI-Y-kaken 2021-5p.pdf","filesize":[{"value":"875.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-HAMAGUCHI-Y-kaken 2021-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51135/files/ME-PR-HAMAGUCHI-Y-kaken 2021-5p.pdf"},"version_id":"c399a6ff-597b-444b-91b4-b0c55b3c5ac3"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"免疫沈降法による膠原病患者血清中の自己抗体の同定と臨床的特徴の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"免疫沈降法による膠原病患者血清中の自己抗体の同定と臨床的特徴の検討"},{"subitem_title":"Identification of autoantibodies by immunoprecipitation assays and clinical characteristics in patients with connective tissue diseases","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4014"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-04"},"publish_date":"2022-02-04","publish_status":"0","recid":"51135","relation_version_is_last":true,"title":["免疫沈降法による膠原病患者血清中の自己抗体の同定と臨床的特徴の検討"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:52:20.152118+00:00"}