{"created":"2023-07-27T06:55:20.274459+00:00","id":51139,"links":{},"metadata":{"_buckets":{"deposit":"32689476-bf10-4977-89ba-9b0d3b68a4a3"},"_deposit":{"created_by":18,"id":"51139","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51139"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051139","sets":["2812:2813:4085"]},"author_link":["76702","2861"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-06-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2018-04-01 – 2022-03-31","bibliographic_titles":[{"bibliographic_title":"令和3(2021)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2021 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Because Enterococci are opportunistic pathogens, colonization and proliferation of Enterococci should be regulated. In mouse liver carcinogenesis model, transplantation of microbiota derived from healthy donors suppressed proliferation of E. faecalis in the gut, resulting in decrease of the number of liver tumors. In mouse colitis model, microbiota of healthy donors suppressed proliferation of E. faecalis, but prednisolone enabled colonization of E. faecium due to decrease of mucin and antimicrobial peptide. Thus, factors regulating Enterococci were clarified in this study.","subitem_description_type":"Abstract"},{"subitem_description":"Enterococcus属は常在腸内細菌だが、免疫力の低下した宿主には病原性を持つ細菌であり、その存在を制御することが求められている。肝癌モデルマウスにおいて、健常な腸内細菌叢の移植がE. faecalisの腸内での増殖を抑制した。その結果、肝腫瘍数も減少させた。潰瘍性大腸炎モデルマウスにおいては、健常者の細菌叢の移植により、E. faecium腸炎を抑制する。しかし、プレドニゾロンを内服していると、腸管からのムチンの分泌が抑制され、抗菌ペプチドの量も減少した。その結果、E. faeciumが増殖することが分かった。Enterococcusを制御する細菌叢や宿主の因子について解明した。","subitem_description_type":"Abstract"},{"subitem_description":"腸内細菌叢が人の健康と疾患に大きな役割を持つことが解明されてきた。しかし100種類以上かつ100兆個近い細菌を含む腸内細菌叢は複雑であり、腸内細菌叢を制御する治療手段は未だ十分に発達していない。細菌叢の構成はpH、酸素含有量、栄養素含有量、抗菌物質の存在、ホストの免疫など腸内環境に制御され決定される。そのため、それらの因子を決定する細菌と細菌の相互作用、細菌とホスト細胞の相互作用の解明が求められているが十分には解明されていない。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18K07904, 研究期間(年度):2018-04-01 – 2022-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「発癌と炎症を促進するEnterococcus属を取り巻く腸内環境の解明」課題番号18K07904\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K07904/18K07904seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院消化器内科","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057442","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40705604"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40705604","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07904/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07904/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K07904/18K07904seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K07904/18K07904seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-02"}],"displaytype":"detail","filename":"HO-PR-IIDA-N-kaken 2022-5p.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-IIDA-N-kaken 2022-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51139/files/HO-PR-IIDA-N-kaken 2022-5p.pdf"},"version_id":"8ae28970-3ad4-4dc4-9dab-ba7c4889b6b9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"発癌と炎症を促進するEnterococcus属を取り巻く腸内環境の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"発癌と炎症を促進するEnterococcus属を取り巻く腸内環境の解明"},{"subitem_title":"Roles of Enterococcus in carcinogenesis and inflammation","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4085"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-03-02"},"publish_date":"2023-03-02","publish_status":"0","recid":"51139","relation_version_is_last":true,"title":["発癌と炎症を促進するEnterococcus属を取り巻く腸内環境の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:21:09.600932+00:00"}