{"created":"2023-07-27T06:55:21.904862+00:00","id":51177,"links":{},"metadata":{"_buckets":{"deposit":"0adca848-c25f-45b0-ad51-aac3766afdda"},"_deposit":{"created_by":18,"id":"51177","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51177"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051177","sets":["2812:2813:4014"]},"author_link":["82220","29"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-06-15","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"13p.","bibliographicVolumeNumber":"2018-04-01 - 2021-03-31","bibliographic_titles":[{"bibliographic_title":"令和2(2020)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2020 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"膜輸送体は細胞膜に局在し、薬物の細胞内への取り込みや細胞内からの排出に働く。本研究は、小腸、肝臓、腎臓、血液脳関門等に発現し、多くの薬物を細胞内から細胞外へ排出する膜輸送体であるbreast cancer resistance protein(BCRP)とP-glycoprotein(P-gp)に着目し、生体内に存在し、これらの基質となり、これら膜輸送体の阻害薬投与により血中濃度が変化する化合物（バイオマーカー）の特定を試みた。網羅的メタボロミクス解析によりイソフラボンの硫酸抱合体がBCRPの生体内基質に、食物由来のステロイド様化合物がP-gpの生体内基質であることが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Membrane transporters are localized on plasma membranes of various cells and involved in the uptake and efflux of substrate drugs. This study focused on two drug efflux transporters, breast cancer resistance protein (BCRP) and P-glycoprotein (P-gp), both of which are expressed in the intestine, liver, kidney, and blood-brain barrier. Many drugs are pumped out by these transporters, and therefore, administration of their inhibitor drugs may lead to change in pharmacokinetics, efficacy, and/or toxicity of their substrate drugs. We have attempted to identify compounds which exist in the body, are transported by these transporters, and whose blood concentration is changed by administration of inhibitor drugs. Comprehensive metabolomics analysis has clarified that sulfate conjugates of isoflavones and food-derived steroid-like compounds are the in vivo substrates of BCRP and P-gp, respectively. We proposed the first evidence of a surrogate marker of BCRP inhibition.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18H02584, 研究期間(年度):2018-04-01 - 2021-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「構造選択的メタボロームと生合成・消失臓器解析によるABC膜輸送体生体内基質の探索」研究成果報告書　課題番号18H02584\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18H02584/18H02584seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057480","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30251440"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30251440","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02584/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02584/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18H02584/18H02584seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18H02584/18H02584seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-04"}],"displaytype":"detail","filename":"PH-PR-KATO-Y-kaken 2021-13p.pdf","filesize":[{"value":"481.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-KATO-Y-kaken 2021-13p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51177/files/PH-PR-KATO-Y-kaken 2021-13p.pdf"},"version_id":"d39983d2-9fde-46cd-b13b-8f1c66ae404b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"構造選択的メタボロームと生合成・消失臓器解析によるABC膜輸送体生体内基質の探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"構造選択的メタボロームと生合成・消失臓器解析によるABC膜輸送体生体内基質の探索"},{"subitem_title":"Structure-selective metabolome analysis of ABC xenobiotic transporters","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4014"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-04"},"publish_date":"2022-02-04","publish_status":"0","recid":"51177","relation_version_is_last":true,"title":["構造選択的メタボロームと生合成・消失臓器解析によるABC膜輸送体生体内基質の探索"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:52:12.557140+00:00"}