{"created":"2023-07-27T06:55:22.862969+00:00","id":51200,"links":{},"metadata":{"_buckets":{"deposit":"59fa869e-29b7-429e-955b-b634a0c04679"},"_deposit":{"created_by":18,"id":"51200","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51200"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051200","sets":["2812:2813:4014"]},"author_link":["86825","92626"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-06-01","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"9p.","bibliographicVolumeNumber":"2018-06-29 - 2021-03-31","bibliographic_titles":[{"bibliographic_title":"令和2(2020)年度 科学研究費補助金 挑戦的研究(萌芽) 研究成果報告書"},{"bibliographic_title":"2020 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"肝臓から分泌されるセレノプロテインP（SeP）が運動抵抗性を誘導することを見出したことから、肝臓でのSeP発現を特異的に抑制し、運動効果を高める低分子化合物を同定するため、既存薬スクリーニングを行った。その結果、SePの転写活性を強力に抑制する低分子既存薬化合物を約50種類同定した。これらの中から毒性の低い3種類の化合物を選び、肝臓細胞株やマウス個体に投与し、SeP発現抑制効果を確認することができた。","subitem_description_type":"Abstract"},{"subitem_description":"Since we found that selenoprotein P (SeP) secreted by the liver induces resistance to exercise, we conducted a screening to identify small-molecule compounds that specifically suppress SeP expression in the liver and enhance the exercise effect. As a result, we identified about 50 small-molecule compounds that potently suppress the transcriptional activity of SeP. Among these, we selected three compounds with low toxicity. We administered these compounds to liver cell lines and mice and confirmed the inhibitory effect on SeP expression.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18K19560, 研究期間(年度):2018-06-29 - 2021-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「肝臓-骨格筋連関を標的とした運動効果増強薬の開発」研究成果報告書　課題番号18K19560\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K19560/18K19560seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057503","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00324111"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00324111","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K19560/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K19560/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K19560/18K19560seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K19560/18K19560seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-03"}],"displaytype":"detail","filename":"ME-PR-TAKAMURA-T-kaken 2021-9p.pdf","filesize":[{"value":"481.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-TAKAMURA-T-kaken 2021-9p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51200/files/ME-PR-TAKAMURA-T-kaken 2021-9p.pdf"},"version_id":"b8836249-b580-47b3-937b-62e4a48b46a1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肝臓-骨格筋連関を標的とした運動効果増強薬の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝臓-骨格筋連関を標的とした運動効果増強薬の開発"},{"subitem_title":"Development of exercise-enhancing therapy targeting the liver-skeletal muscle network","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4014"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-03"},"publish_date":"2022-02-03","publish_status":"0","recid":"51200","relation_version_is_last":true,"title":["肝臓-骨格筋連関を標的とした運動効果増強薬の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:53:03.112976+00:00"}