{"created":"2023-07-27T06:55:23.180888+00:00","id":51207,"links":{},"metadata":{"_buckets":{"deposit":"9dc23b8d-d6b5-4d8f-a7ed-b6087b0a33d4"},"_deposit":{"created_by":18,"id":"51207","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51207"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051207","sets":["2812:2813:4014"]},"author_link":["2482","24080"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-06-04","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"8p.","bibliographicVolumeNumber":"2019-06-28 - 2021-03-31","bibliographic_titles":[{"bibliographic_title":"令和2(2020)年度 科学研究費補助金 挑戦的研究(萌芽) 研究成果報告書"},{"bibliographic_title":"2020 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"複数の生活習慣病を対象とし、地域住民コホート参加者それぞれの各種疾患の発症にかかる遺伝的リスク（ゲノムワイド多遺伝子リスクスコアGPS）を推定し、各種疾患における疾患発症ハイリスク群を特定した。加えて、ベースライン調査結果（生活習慣、既往症等）や診療情報（合併症、投薬履歴等）、遺伝子型情報などに基づく発症-未発症群間の比較解析を行い、疾患発症にかかる統計学的に有意な因子を見出し、疾患未発症者に共通する発症抑制因子候補（遺伝・環境因子）を特定した。","subitem_description_type":"Abstract"},{"subitem_description":"We estimated genome-wide polygenic risk scores (GPSs) for the development of various lifestyle-related diseases in each of the community-based cohort participants, and identified high-risk groups for developing the diseases based on GPSs. Further, we performed population-based case-control studies using baseline data (e.g., blood testing, lifestyle), medical information (e.g., complications, medication history) and genotypes, and found candidate factors (genetic and environmental factors) that could inhibit the development of lifestyle-related diseases.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19K22753, 研究期間(年度):2019-06-28 - 2021-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「遺伝的リスクスコアに基づく生活習慣病ハイリスク群における発症抑制因子の同定」研究成果報告書　課題番号19K22753\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19K22753/19K22753seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057510","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10396864"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10396864","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22753/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22753/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19K22753/19K22753seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19K22753/19K22753seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-03"}],"displaytype":"detail","filename":"ME-PR-TAJIMA-A-kaken 2021-8p.pdf","filesize":[{"value":"422.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-TAJIMA-A-kaken 2021-8p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51207/files/ME-PR-TAJIMA-A-kaken 2021-8p.pdf"},"version_id":"9a1cdfde-3a9e-4c34-9cf5-b686c778b7e7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"遺伝的リスクスコアに基づく生活習慣病ハイリスク群における発症抑制因子の同定","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"遺伝的リスクスコアに基づく生活習慣病ハイリスク群における発症抑制因子の同定"},{"subitem_title":"Identification of inhibitory factors for the development of lifestyle-related diseases in high-risk groups based on genetic risk scores","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4014"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-03"},"publish_date":"2022-02-03","publish_status":"0","recid":"51207","relation_version_is_last":true,"title":["遺伝的リスクスコアに基づく生活習慣病ハイリスク群における発症抑制因子の同定"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:53:01.534366+00:00"}