{"created":"2023-07-27T06:55:23.271311+00:00","id":51211,"links":{},"metadata":{"_buckets":{"deposit":"f12f27ff-4865-4750-b09e-9bc0aa6fc4a5"},"_deposit":{"created_by":18,"id":"51211","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51211"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051211","sets":["2812:2813:4085"]},"author_link":["92638","249"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-06","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2019-04-01 - 2022-03-31","bibliographic_titles":[{"bibliographic_title":"令和3(2021)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2021 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sato, Yasunori"}],"nameIdentifiers":[{"nameIdentifier":"92638","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30324073","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30324073"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This study revealed that activation of the Notch-Hes1 signaling pathway was critically involved in biliary cystogenesis of Caroli disease with congenital hepatic fibrosis (CHF) as well as the polycystic kidney (PCK) rat, an animal model of Caroli disease with CHF. In vitro experiments using PCK cholangiocytes showed that administration of Notch inhibitor (FLI-06) significantly inhibited cell proliferative activity. The inhibition was accompanied by the induction of apoptosis, but not cellular senescence. These results indicate that inhibition of the Notch signaling represents a potential target of therapy for Caroli disease with congenital hepatic fibrosis.","subitem_description_type":"Abstract"},{"subitem_description":"Caroli病 + 先天性肝線維症とその動物モデルであるPCKラットの肝組織を用いた検討で，胆管細胞におけるNotch-Hes1を介した細胞内シグナル伝達の亢進が進行性の肝内胆管拡張に関与していることを明らかにした。PCKラットの培養胆管細胞にNotch阻害剤（FLI-06）を投与すると胆管細胞にアポトーシスが誘導され，過剰な細胞増殖が抑制された。FLI-06は胆管細胞に細胞老化を誘導することはなかったが，Notchシグナル伝達系はCaroli病＋先天性肝線維症の新たな治療標的となる可能性が示された。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19K07458, 研究期間(年度):2019-04-01 - 2022-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「胆管細胞老化に着目した肝線維性多嚢胞性疾患の新たな治療法の開発」課題番号19K07458\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K07458/19K07458seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057514","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30324073"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30324073","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K07458/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K07458/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K07458/19K07458seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K07458/19K07458seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"佐藤, 保則"}],"nameIdentifiers":[{"nameIdentifier":"249","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30324073","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30324073"},{"nameIdentifier":"30324073","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=30324073"},{"nameIdentifier":"30324073","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000030324073"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-03"}],"displaytype":"detail","filename":"ME-PR-SATO-Y-kaken 2022-6p.pdf","filesize":[{"value":"460.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SATO-Y-kaken 2022-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51211/files/ME-PR-SATO-Y-kaken 2022-6p.pdf"},"version_id":"c83dcba0-56fb-44a0-8f9a-cbd1de56935b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"胆管細胞老化に着目した肝線維性多嚢胞性疾患の新たな治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胆管細胞老化に着目した肝線維性多嚢胞性疾患の新たな治療法の開発"},{"subitem_title":"Development of a novel therapeutic approach for fibropolycystic liver disease focusing on cellular senescence of cholangiocytes","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4085"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-02-03"},"publish_date":"2023-02-03","publish_status":"0","recid":"51211","relation_version_is_last":true,"title":["胆管細胞老化に着目した肝線維性多嚢胞性疾患の新たな治療法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:18:16.873274+00:00"}