{"created":"2023-07-27T06:55:23.948954+00:00","id":51230,"links":{},"metadata":{"_buckets":{"deposit":"66ac6afc-ad9a-4126-b5a9-39ba19a8b51f"},"_deposit":{"created_by":18,"id":"51230","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51230"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051230","sets":["2812:2813:4085"]},"author_link":["88136","88137"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-06-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"9p.","bibliographicVolumeNumber":"2018-04-01 - 2022-03-31","bibliographic_titles":[{"bibliographic_title":"令和3(2021)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2021 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In macrophages infected, for example, by bacteria, the innate immune mechanism inflammasome is activated, which in turn induces the activation of the proteolytic enzyme caspase-1, leading to inflammatory programme cell death called pyrotosis. We found that the therapeutic effect of ampicillin administration during Listeria infection is promoted by an inflammasome and investigated the molecular mechanism of the improved therapeutic efficacy. We found that Listeria trapped within intracellular vacuoles become resistant to ampicillin treatment and prevent complete bacterial elimination, and that induction of pyrotosis is necessary to eliminate Listeria in the vacuoles. From this study, a co-ordinated action of antibiotic treatment and the immune system was revealed.","subitem_description_type":"Abstract"},{"subitem_description":"細菌などに寄生されたマクロファージでは、自然免疫機構であるインフラマソームが活性化し、蛋白分解酵素カスパーゼ1の活性化を誘導することで、パイロトーシスと呼ばれる炎症性プログラム細胞死が起こる。我々は、リステリア感染時におけるアンピシリン投与の治療効果がインフラマソームによって促進される現象を見出し、その分子機序の解明を行った。その結果、細胞内の小胞内に捕捉されたリステリアがアンピシリン処理に耐性を示して完全な菌排除を妨げること、また、このような状態のリステリアを排除するためにはパイロトーシスの誘導が必要であることを見出した。抗生物質治療と免疫系の協調的作用が明らかになった。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18K07106, 研究期間(年度):2018-04-01 - 2022-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「細菌感染治療の分子基盤を自然免疫機構と化学療法の協調的相互作用から理解する試み」課題番号18K07106\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K07106/18K07106seika/ ）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057533","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50437216"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50437216","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07106/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07106/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K07106/18K07106seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K07106/18K07106seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-27"}],"displaytype":"detail","filename":"CA-PR-TSUCHIYA-K-kaken 2022-9p.pdf","filesize":[{"value":"394.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-TSUCHIYA-K-kaken 2022-9p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51230/files/CA-PR-TSUCHIYA-K-kaken 2022-9p.pdf"},"version_id":"b095cb64-32bf-450a-b8a6-d25ec5896093"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"細菌感染治療の分子基盤を自然免疫機構と化学療法の協調的相互作用から理解する試み","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"細菌感染治療の分子基盤を自然免疫機構と化学療法の協調的相互作用から理解する試み"},{"subitem_title":"Host-pathogen interactions in antibiotic therapy for listeriosis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4085"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-02-27"},"publish_date":"2023-02-27","publish_status":"0","recid":"51230","relation_version_is_last":true,"title":["細菌感染治療の分子基盤を自然免疫機構と化学療法の協調的相互作用から理解する試み"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:21:29.631419+00:00"}