{"created":"2023-07-27T06:55:24.085305+00:00","id":51233,"links":{},"metadata":{"_buckets":{"deposit":"19dc6546-827b-4435-94fa-db90a9b96d64"},"_deposit":{"created_by":18,"id":"51233","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51233"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051233","sets":["2812:2813:4085"]},"author_link":["88151"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-06-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"7p.","bibliographicVolumeNumber":"2019-04-01 - 2022-03-31","bibliographic_titles":[{"bibliographic_title":"令和3(2021)年度 科学研究費補助金 若手研究 研究成果報告書"},{"bibliographic_title":"2021 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ketut, Gunarta"}],"nameIdentifiers":[{"nameIdentifier":"88151","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90838393","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90838393"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The ROS level is tightly regulated by a cell as it can oxidize molecules inside a cell and ultimately lead to cell death. ROS inducing agent, such as curcumin, has been reported to alter lysosome localization in a cancer cell. We found that JSAP, a family of motor protein adaptors, is involved in lysosome transport in response to curcumin. We also clarified the relationship between JSAP-mediated lysosome transport and curcumin-induced cell death in cancer. Our study suggested that the closely related member of the JSAP family, JSAP1 and JSAP2 (also known as JLP), play a distinct function in curcumin-induced stress.","subitem_description_type":"Abstract"},{"subitem_description":"ROSレベルは、細胞内の分子を酸化し、最終的に細胞死を引き起こす可能性があるため、細胞によって厳密に制御されています。 クルクミンなどのROS誘導剤は、癌細胞のリゾソーム局在を変化させることが報告されています。 モータータンパク質アダプターのファミリーであるJSAPが、クルクミンに応答したリソソーム輸送に関与していることを発見しました。 また、JSAPを介したリソソーム輸送とクルクミンによる細胞死の関係を明らかにしました。 私たちの研究は、JSAPファミリーの密接に関連するメンバーであるJSAP1とJSAP2がクルクミン誘発性ストレスにおいて異なる機能を果たしていることを示唆しました。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19K16737, 研究期間(年度):2019-04-01 - 2022-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「Role of kinesin/dynein adaptor JSAP in reactive oxygen species-induced cell death and lysosome positioning」課題番号19K16737\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K16737/19K16737seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057536","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=90838393"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=90838393","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K16737/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K16737/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K16737/19K16737seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K16737/19K16737seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ketut, Gunarta"}],"nameIdentifiers":[{"nameIdentifier":"88151","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90838393","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90838393"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-03"}],"displaytype":"detail","filename":"CA-PR-KETUT-G-kaken 2022-7p.pdf","filesize":[{"value":"195.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-KETUT-G-kaken 2022-7p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51233/files/CA-PR-KETUT-G-kaken 2022-7p.pdf"},"version_id":"516bd633-6f05-41a2-af7e-ba3bf6c05874"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"Role of kinesin/dynein adaptor JSAP in reactive oxygen species-induced cell death and lysosome positioning","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Role of kinesin/dynein adaptor JSAP in reactive oxygen species-induced cell death and lysosome positioning"},{"subitem_title":"Role of kinesin/dynein adaptor JSAP in reactive oxygen species-induced cell death and lysosome positioning","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4085"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-02-03"},"publish_date":"2023-02-03","publish_status":"0","recid":"51233","relation_version_is_last":true,"title":["Role of kinesin/dynein adaptor JSAP in reactive oxygen species-induced cell death and lysosome positioning"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:15:54.334524+00:00"}