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Investigation of putative roles for GSK3b in glioblastoma stemness phenotype and the underlying biological mechanisms
https://doi.org/10.24517/00057537
https://doi.org/10.24517/00057537b7786d8b-f1bd-4c7a-a486-ded4d3ef399a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
CA-PR-PYKO-I-kaken 2021-2p.pdf (98.0 kB)
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| Item type | 報告書 / Research Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-03-03 | |||||
| タイトル | ||||||
| タイトル | Investigation of putative roles for GSK3b in glioblastoma stemness phenotype and the underlying biological mechanisms | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
| 資源タイプ | research report | |||||
| ID登録 | ||||||
| ID登録 | 10.24517/00057537 | |||||
| ID登録タイプ | JaLC | |||||
| 著者 |
Pyko, Ilya
× Pyko, Ilya |
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| 書誌情報 |
令和1(2019)年度 科学研究費補助金 若手研究 研究概要 en : 2019 Research Project Summary 巻 2018-04-01 - 2020-03-31, p. 2p., 発行日 2021-01-27 |
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| 出版者 | ||||||
| 出版者 | 金沢大学がん進展制御研究所 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Studies in vitro and in animal model were carried out complementary to optimize treatment of glioblastoma (GBM) by enhancing anti-tumor effect by combination of GSK3β inhibition and temozolomide (TMZ). For in vitro study, we examined effect of GSK3β inhibition and TMZ on patient derived GBM stem-like cells (SCs). I found that GSK3β inhibition enhances effect of TMZ against GBM-SCs and participate in regulation of GBM stemness phenotype. For animal model study, I have developed software pharmacokinetics model and determined optimal concentration of GSK3β inhibitor for continuous intra-tumor infusion by subcutaneous pumps for treatment of orthotopic GBM models and examined the effects of continuous intra-tumor infusion of GSK3β inhibitor, against GBM in mice bearing human GBM-SCs. Our experiments showed that GSK3β inhibition is effective for treatment of experimental GBM generated by inoculation of most malignant GBM-SCs characterized by shortest survival in control animals. We investigated biological mechanisms by which GSK3β regulate GBM stemness phenotype and revealed changes in stem cell markers’ expression in GBM-SCs under GSK3β inhibition, which can be associated with regulation of GBM stemness phenotype by GSK3β via multiple signaling pathways. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 研究課題/領域番号:18K16553, 研究期間(年度):2018-04-01 - 2020-03-31 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 出典：「Investigation of putative roles for GSK3b in glioblastoma stemness phenotype and the underlying biological mechanisms」研究成果報告書 課題番号18K16553 （KAKEN：科学研究費助成事業データベース（国立情報学研究所）） （https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18K16553/）を加工して作成 |
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| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://kaken.nii.ac.jp/search/?qm=00731853 | |||||
| 関連名称 | https://kaken.nii.ac.jp/search/?qm=00731853 | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K16553/ | |||||
| 関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K16553/ | |||||
