{"created":"2023-07-27T06:55:26.099880+00:00","id":51281,"links":{},"metadata":{"_buckets":{"deposit":"ca0c104e-979f-42e0-8d46-bff24b7c2ddd"},"_deposit":{"created_by":18,"id":"51281","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51281"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051281","sets":["2812:2813:4014"]},"author_link":["88886","88885"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-06-07","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"8p.","bibliographicVolumeNumber":"2019-04-01 - 2021-03-31","bibliographic_titles":[{"bibliographic_title":"令和2(2020)年度 科学研究費補助金 若手研究 研究成果報告書"},{"bibliographic_title":"2020 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、HLA-B5401欠失血球陽性の再生不良性貧血（再不貧）の免疫病態と、HLA-B5401が提示する自己抗原を明らかにすることを目的とした。HLA-B5401欠失血球陽性の再不貧患者から、抗原特異的に優勢に増殖しているT細胞レセプター（T-cell receptor: TCR）の配列を同定した。また、再不貧患者のHLA-Aアレル、Bアレルに共通してみられるexon1領域のミスセンス変異を同定し、この変異を高感度で検出できるdroplet digital PCRを開発した。HLA-Bアレルにおいて、HLA-B5401の変異はHLA-B4002についで2番目に多いことが明らかになった。","subitem_description_type":"Abstract"},{"subitem_description":"The purpose of the study is to understand pathophysiology in aplastic anemia (AA) patients with HLA-B*54:01 lacking cells and autoantigens presented by HLA-B5401. We identified T-cell receptor sequence in AA patients with HLA-B5401 lacking cells. We also identified a common nonsense mutation in exon 1 of different HLA-A and -B alleles in HLA-lacking granulocytes from AA patients. A droplet digital PCR (ddPCR) assay revealed that HLA-B*54:01 mutation was the second most frequent HLA-B allele in AA patients.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19K17823, 研究期間(年度):2019-04-01 - 2021-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「HLA-B*54:01陽性造血不全患者における免疫病態の解明」研究成果報告書　課題番号19K17823\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19K17823/19K17823seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057584","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院高密度無菌治療部"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10786239"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10786239","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K17823/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K17823/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19K17823/19K17823seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19K17823/19K17823seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-10"}],"displaytype":"detail","filename":"HO-PR-HOSOKAWA-K-kaken 2021-8p.pdf","filesize":[{"value":"83.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-HOSOKAWA-K-kaken 2021-8p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51281/files/HO-PR-HOSOKAWA-K-kaken 2021-8p.pdf"},"version_id":"c7e860ff-f43a-41c9-bde4-a2fecde47171"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"HLA-B*54:01陽性造血不全患者における免疫病態の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"HLA-B*54:01陽性造血不全患者における免疫病態の解明"},{"subitem_title":"Understanding the immune pathophysiology in bone marrow failure patients with HLA-B*54:01","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4014"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-10"},"publish_date":"2022-02-10","publish_status":"0","recid":"51281","relation_version_is_last":true,"title":["HLA-B*54:01陽性造血不全患者における免疫病態の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:51:31.785995+00:00"}