{"created":"2023-07-27T06:55:26.190915+00:00","id":51283,"links":{},"metadata":{"_buckets":{"deposit":"b2cb724a-90eb-4aa2-8d3e-5485235049b7"},"_deposit":{"created_by":18,"id":"51283","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51283"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051283","sets":["2812:2813:4085"]},"author_link":["88889","88890"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-06-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2018-04-01 - 2022-03-31","bibliographic_titles":[{"bibliographic_title":"令和3(2021)年度 科学研究費補助金 若手研究 研究成果報告書"},{"bibliographic_title":"2021 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Okafuji, Hirofumi"}],"nameIdentifiers":[{"nameIdentifier":"88890","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20772958","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20772958"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The purpose of this study was to clarify the efficacy and complications of stool microflora transplantation, a new treatment for inflammatory bowel disease, which has been increasing in recent years. As a result, three patients with ulcerative colitis showed remission and no complications. In the process, we noticed that the effect was not good in steroid-dependent patients, so we added a mouse experiment. Administration of steroids to mice decreased mucin, which protects the colonic mucosa, and further altered the bacterial flora. When the mice were supplemented with mucin and then underwent fecal transplantation in steroid-treated mice, it was found that the treatment was more effective in the supplemented mice than in the non-supplemented mice. Colonic mucin regulates the intestinal microbiota, and steroids decreased colonic mucin and altered the intestinal microbiota.","subitem_description_type":"Abstract"},{"subitem_description":"本研究では、近年増加している炎症性腸疾患の新しい治療、便細菌叢移植に関して効果及び合併症などを明らかにすることを目的とした。結果、潰瘍性大腸炎患者3名が寛解し、合併症は認めなかった。その過程で、ステロイド依存患者では効果が乏しいことに気づきマウス実験を追加した。マウスにステロイドを投与すると、大腸粘膜を保護するムチンを減少させさらに細菌叢を変化させた。ムチンを補充して、ステロイド投与マウスに便移植行うと、ムチンを補充しないマウスに比べて補充した方が便移植の治療効果が高いことが分かった。大腸ムチンは腸内細菌叢を制御し、ステロイドは大腸ムチンを減少させ腸内細菌叢を変化させていることが分かった。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18K15746, 研究期間(年度):2018-04-01 - 2022-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「便細菌叢移植による腸内細菌叢の変化」研究成果報告書　課題番号18K15746\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K15746/18K15746seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院集中治療部","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057586","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20772958"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20772958","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K15746/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K15746/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K15746/18K15746seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K15746/18K15746seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岡藤, 啓史"}],"nameIdentifiers":[{"nameIdentifier":"88889","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20772958","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20772958"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-27"}],"displaytype":"detail","filename":"HO-PR-OKAFUJI-H-kaken 2022-5p.pdf","filesize":[{"value":"406.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-OKAFUJI-H-kaken 2022-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51283/files/HO-PR-OKAFUJI-H-kaken 2022-5p.pdf"},"version_id":"e9b5afbe-965b-44ac-b21f-08961a9dffc0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"便細菌叢移植による腸内細菌叢の変化","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"便細菌叢移植による腸内細菌叢の変化"},{"subitem_title":"Changes in intestinal microbiota by FMT","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4085"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-02-27"},"publish_date":"2023-02-27","publish_status":"0","recid":"51283","relation_version_is_last":true,"title":["便細菌叢移植による腸内細菌叢の変化"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:18:19.067721+00:00"}