{"created":"2023-07-27T06:55:26.283639+00:00","id":51285,"links":{},"metadata":{"_buckets":{"deposit":"324e62d6-fe23-40cd-bf47-6a9d155fcb37"},"_deposit":{"created_by":18,"id":"51285","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51285"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051285","sets":["2812:2813:4014"]},"author_link":["45604","2692"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-06-06","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2018-04-01 – 2021-03-31","bibliographic_titles":[{"bibliographic_title":"令和2(2020)年度 科学研究費補助金 若手研究 研究成果報告書"},{"bibliographic_title":"2020 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"くも膜下出血モデルを野生型マウスとATF6ノックアウトマウスにて作成し、比較検討を行うと、モデル作成24時間後の時点で神経学的所見の明らかな差は見いだせなかった。また、脳をとりだし、算出される水分含有割合で脳浮腫の程度の比較を行ったが、こちらも明らかな差を認めなかった。\nくも膜下出血群としたものと、sham群にて小胞体ストレス応答がどのように生じているか比較すると、くも膜下出血群では、小胞体ストレス応答の主幹転写因子であるATF6の発現がsham群より有意に多くみられ、下流の分子シャペロンのGRP78やCHOPも多く発現しており、小胞体ストレス応答が誘導されていることが確認された。","subitem_description_type":"Abstract"},{"subitem_description":"Subarachnoid hemorrhage model was created in wild-type mice and ATF6 knockout mice and compared, no clear difference in neurological findings was found 24 hours after model creation. In addition, the brain was taken out and the degree of cerebral edema calculated water content ratio was compared, however no clear difference was observed here either.\nComparing how the endoplasmic reticulum stress response occurs in the subarachnoid hemorrhage group and the sham group, the expression of ATF6, which is the main transcription factor of the endoplasmic reticulum stress response, is higher in the subarachnoid hemorrhage group than in the sham group. It was significantly abundant, and the downstream molecular chaperones GRP78 and CHOP were also highly expressed, confirming that the endoplasmic reticulum stress response was induced.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18K16554, 研究期間(年度):2018-04-01 – 2021-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「くも膜下出血後 EBI と小胞体ストレス応答 UPR の関連についての検討」研究成果報告書　課題番号18K16554\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K16554/18K16554seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057588","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院脳神経外科"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30646691"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30646691","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K16554/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K16554/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K16554/18K16554seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K16554/18K16554seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-28"}],"displaytype":"detail","filename":"HO-PR-YOSHIKAWA-A-kaken 2021-4p.pdf","filesize":[{"value":"73.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-YOSHIKAWA-A-kaken 2021-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51285/files/HO-PR-YOSHIKAWA-A-kaken 2021-4p.pdf"},"version_id":"2a00a628-faac-4843-8e7b-d5871b49f116"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"くも膜下出血後EBI と小胞体ストレス応答UPRの関連についての検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"くも膜下出血後EBI と小胞体ストレス応答UPRの関連についての検討"},{"subitem_title":"Examination of the relationship between early brain injury of post-subarachnoid hemorrhage and unfolded protein response of endoplasmic reticulum stress","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4014"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-28"},"publish_date":"2022-02-28","publish_status":"0","recid":"51285","relation_version_is_last":true,"title":["くも膜下出血後EBI と小胞体ストレス応答UPRの関連についての検討"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:44:03.577047+00:00"}