{"created":"2023-07-27T06:55:28.109091+00:00","id":51418,"links":{},"metadata":{"_buckets":{"deposit":"51550a0b-3a09-45f8-ba0d-121e3b3c6cc0"},"_deposit":{"created_by":18,"id":"51418","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51418"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051418","sets":["2812:2813:2817"]},"author_link":["92856","92857"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"急性骨髄性白血病（AML）は、造血幹・前駆細胞を起源として発生する悪性腫瘍であり、その病態は異常増殖と分化ブロックに起因する。本研究では、白血病幹細胞の未分化性維持に寄与する栄養シグナルと分化プログラムを結ぶ分子としてFOXOに着目して解析した。 AML細胞株にFOXOを特異的に阻害し、遺伝子発現解析、メタボローム解析、代謝遺伝子変動解析を行った。その結果、FOXOは白血病の分化を直接制御するのみではなく、グルコースを中心とした栄養シグナルにより活性調節を受け、白血病細胞の生存調節に寄与しているものと考えられた。今後、新たな白血病治療の標的として、FOXOが有用であることが期待される。","subitem_description_type":"Abstract"},{"subitem_description":"Myeloid leukemias are essentially hematopoiesis gone awry at hematopoietic stem cells(HSCs)/progenitor cells. Forkhead members of the class O transcription factor (FOXO), plays a critical role of maintenance of HSCs, leukemia initiating cells. In this study, we attempted to establish a system for identification of molecules regulating differentiation blockade of leukemia stem cells by monitoring FOXO activity. Analysis of effects of the pharmaceutical inactivation of FOXO on leukemia differentiation revealed unique FOXO function in maintaining LSCs and coupling it with cellular metabolism. FOXO inhibition induced glycolysis and consequently increased apoptosis and cell differentiation, thereby suppressing tumor formation in vivo. These results indicate that FOXO is involved in metabolic reprograming and differentiation in LSCs, and thus is a promising target for leukemia.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K19548, 研究期間(年度):2015-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「白血病幹細胞の未分化性制御での代謝リプログラミングの役割」研究成果報告書　課題番号15K19548\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K19548/15K19548seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057721","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん進展制御研究所"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30416177"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30416177","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K19548/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K19548/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K19548/15K19548seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K19548/15K19548seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-20"}],"displaytype":"detail","filename":"CA-PR-OHTA-K-kaken 2017-4p.pdf","filesize":[{"value":"152.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-OHTA-K-kaken 2017-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51418/files/CA-PR-OHTA-K-kaken 2017-4p.pdf"},"version_id":"b81d3a15-c784-4505-91d1-cbd69be2830a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"白血病幹細胞の未分化性制御での代謝リプログラミングの役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"白血病幹細胞の未分化性制御での代謝リプログラミングの役割"},{"subitem_title":"Role of metabolic regulation in leukemia stem cells","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-20"},"publish_date":"2020-04-20","publish_status":"0","recid":"51418","relation_version_is_last":true,"title":["白血病幹細胞の未分化性制御での代謝リプログラミングの役割"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:14:53.719030+00:00"}