{"created":"2023-07-27T06:55:28.426437+00:00","id":51425,"links":{},"metadata":{"_buckets":{"deposit":"0a81e9f3-bd9b-4513-b56b-a7c854d7b1d0"},"_deposit":{"created_by":18,"id":"51425","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51425"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051425","sets":["2812:2813:4014"]},"author_link":["154","13878"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-05-11","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"9p.","bibliographicVolumeNumber":"2018-04-01 - 2021-03-31","bibliographic_titles":[{"bibliographic_title":"令和2(2020)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2020 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"膠芽腫は脳腫瘍の中で最も悪性度が高く、非常に難治性である。膠芽腫に対する新たな治療を開発するためには、腫瘍の増大や進展の分子機構を解明する必要がある。近年、細胞が分泌するエクソソームという細胞外小胞の作用が様々な悪性腫瘍で注目されている。今回われわれは膠芽腫細胞が分泌するエクソソームについて研究した結果、WT1タンパクを含有したエクソソームが膠芽腫細胞から分泌され、それが周囲のマイクログリアに伝播し、血管新生抑制タンパクであるThrombospondin 1がマイクログリア内で低下することで腫瘍形成を促進することを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"Glioblastoma is the most malignant brain tumor. In order to develop new treatments for glioblastoma, it is necessary to elucidate the mechanism of tumor growth and progression. Recently, extracellular vesicles called exosomes, which are secreted by cells, have been attracting attention in various malignant tumors. In this study, we studied the exosomes secreted by glioblastoma cells. We found that the exosomes containing WT1 protein are secreted by glioblastoma cells, then expression of thrombospondin-1, a negative regulator of angiogenesis, was downregulated in surrounding microglia. This intercellular regulatory pathway promotes glioblastoma progression. Our findings establish a novel model of tumor progression via exosome-mediated WT1-Thbs1, which may be a future diagnostic or therapeutic target.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18H02910, 研究期間(年度):2018-04-01 - 2021-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「悪性神経膠腫由来のエクソソームを介したミクログリアによる微小環境整備の解明」研究成果報告書　課題番号18H02910\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18H02910/18H02910seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057728","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20334774"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20334774","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02910/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02910/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18H02910/18H02910seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18H02910/18H02910seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-10"}],"displaytype":"detail","filename":"ME-PR-NAKADA-M-kaken 2021-9p.pdf","filesize":[{"value":"175.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NAKADA-M-kaken 2021-9p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51425/files/ME-PR-NAKADA-M-kaken 2021-9p.pdf"},"version_id":"9327740f-fe0b-4ff3-bba8-3db24eb06388"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"悪性神経膠腫由来のエクソソームを介したミクログリアによる微小環境整備の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"悪性神経膠腫由来のエクソソームを介したミクログリアによる微小環境整備の解明"},{"subitem_title":"Maintenance of tumor microenvironments by extracellular vesicles derived from glioblastoma cells","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4014"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-10"},"publish_date":"2022-02-10","publish_status":"0","recid":"51425","relation_version_is_last":true,"title":["悪性神経膠腫由来のエクソソームを介したミクログリアによる微小環境整備の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:51:13.785776+00:00"}