{"created":"2023-07-27T06:55:29.247822+00:00","id":51450,"links":{},"metadata":{"_buckets":{"deposit":"7869136f-5ea1-4f46-a576-9b286eb86a7d"},"_deposit":{"created_by":18,"id":"51450","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51450"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051450","sets":["2812:2813:3929"]},"author_link":["24503","3004"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-11","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"8p.","bibliographicVolumeNumber":"2017-04-01 - 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、１；EMTが誘導する4D型高浸潤口腔癌細胞や癌関連線維芽細胞の形成過程で発現低下するMMPを特定し、２；PD-L1に対する分解活性を調べ、３；切断部位を同定した。４；PD-L1を分解するMMPのなかで、T細胞の免疫寛容を抑制するMMPを特定した。５；さらにこの免疫寛容を抑制するMMPを安定発現する4D型高浸潤口腔癌細胞や、選択的MMP合成インヒビターを用いてMMPの癌微小環境での腫瘍免疫活性化効果を検証した。浸潤先端部の4D型高浸潤口腔癌細胞がMMPで活性化された腫瘍免疫により低浸潤癌へと変化するかを、マウス口腔癌浸潤転移モデルを用いて検証した。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we adressed to 1; identify MMPs that are reduced in expression during EMT-induced formation of type 4D highly invasive oral cancer cells and cancer-associated fibroblasts; 2; investigate their degradative activity against PD-L1. 3; identify cleavage sites. 4; among MMPs that degrade PD-L1, we identified MMPs that suppress T-cell immune tolerance. 5; in addition, the tumor immune activation effects of MMP in the cancer microenvironment were verified using 4D type high invasion oral cancer cell which stably expresses MMP which suppresses this immune tolerance and selective MMP synthetic inhibitors.\nWe verified whether type 4D highly invasive oral cancer cells at the invasive front were transformed into minimally invasive cancer by tumor immunity activated with MMPs using a murine oral cancer invasive metastatic model.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17K11869, 研究期間(年度):2017-04-01 - 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「口腔癌浸潤先端部微小環境での腫瘍免疫抑制機構の解明」研究成果報告書　課題番号17K11869\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K11869/17K11869seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057753","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30542253"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30542253","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K11869/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K11869/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K11869/17K11869seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K11869/17K11869seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-19"}],"displaytype":"detail","filename":"ME-PR-NAKAMURA-H-kaken 2020-8p.pdf","filesize":[{"value":"90.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NAKAMURA-H-kaken 2020-8p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51450/files/ME-PR-NAKAMURA-H-kaken 2020-8p.pdf"},"version_id":"ef31750c-543b-4fa1-a6ed-61ad30a3185a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"口腔癌浸潤先端部微小環境での腫瘍免疫抑制機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"口腔癌浸潤先端部微小環境での腫瘍免疫抑制機構の解明"},{"subitem_title":"Analysis of Tumor Immunosuppressive Mechanisms in the Oral Cancer Invasive Microenvironment","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-19"},"publish_date":"2021-04-19","publish_status":"0","recid":"51450","relation_version_is_last":true,"title":["口腔癌浸潤先端部微小環境での腫瘍免疫抑制機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:04:26.517072+00:00"}