{"created":"2023-07-27T06:55:29.839744+00:00","id":51467,"links":{},"metadata":{"_buckets":{"deposit":"91f4c02a-260c-4cbb-a14e-6c0a18a14a81"},"_deposit":{"created_by":18,"id":"51467","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51467"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051467","sets":["2812:2813:4085"]},"author_link":["85011","43"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-06-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2019-04-01 - 2022-03-31","bibliographic_titles":[{"bibliographic_title":"令和3(2021)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2021 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shiba, Kazuhiro"}],"nameIdentifiers":[{"nameIdentifier":"85011","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40143929","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40143929"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We investigated the characteristics of radio-iodinated 2-[4-(2-iodophenyl)piperidino]cyclopentanol (OI5V) as a single photon emission computed tomography (SPECT) ligand for mapping sigma-1 receptor, which plays an important role in stress remission in many organs. OI5V demonstrated high selective binding affinity for sigma-1 receptor in vitro. In the biodistribution study, the blood-brain barrier (BBB) permeability of [125I]OI5V was high and the accumulation of [125I]OI5V in the rat cortex. Brain distribution of [125/123I]OI5V in stress model mice showed that the brain accumulation of [125/123I]OI5V increased in the early stage of stress, the brain accumulation of [125/123I]OI5V decreased in the late stage of stress. [123I]OI5V was suggested to be useful as a sigma-1 receptor imaging agent for the early diagnosis and severity diagnosis of stress-related psychiatric disorders.","subitem_description_type":"Abstract"},{"subitem_description":"うつ病、不安障害等のストレス性疾患を客観的かつ超早期に確定診断が可能な新規sigma-1受容体イメージング剤の開発を目指した結果、[125/123I]OI5Vがラット脳内での高い集積性及び脳内でのσ-1受容体結合選択性があることから、[125/123I]OI5Vが優れたσ-1受容体イメージング剤であることを見出した。拘束ストレスモデルマウスを用いた実験により、[125/123I]OI5Vの大脳皮質集積がストレス初期では増加し、ストレス後期では減少した。以上より、[123I]OI5Vがストレス性疾患の客観的・早期確定診断用のsigma-1受容体イメージング剤としての可能性が示された。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19K08197, 研究期間(年度):2019-04-01 - 2022-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「シグマ受容体イメージングによるストレス性疾患の客観的早期診断法の開発」課題番号19K08197\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K08197/19K08197seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学学際科学実験センター","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057770","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40143929"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40143929","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K08197/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K08197/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K08197/19K08197seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19K08197/19K08197seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"柴, 和弘"}],"nameIdentifiers":[{"nameIdentifier":"43","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40143929","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40143929"},{"nameIdentifier":"40143929","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=40143929"},{"nameIdentifier":"40143929","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000040143929"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-03"}],"displaytype":"detail","filename":"ME-PR-SHIBA-K-kaken 2022-6p.pdf","filesize":[{"value":"396.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SHIBA-K-kaken 2022-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51467/files/ME-PR-SHIBA-K-kaken 2022-6p.pdf"},"version_id":"9bfe48df-a631-41ef-9ed6-d7a66ad5a521"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"シグマ受容体イメージングによるストレス性疾患の客観的早期診断法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"シグマ受容体イメージングによるストレス性疾患の客観的早期診断法の開発"},{"subitem_title":"Development of sigma-1 receptor imaging agent for early diagnosis of stress-related diseases","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4085"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-02-03"},"publish_date":"2023-02-03","publish_status":"0","recid":"51467","relation_version_is_last":true,"title":["シグマ受容体イメージングによるストレス性疾患の客観的早期診断法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:18:06.502861+00:00"}