{"created":"2023-07-27T06:55:30.160131+00:00","id":51477,"links":{},"metadata":{"_buckets":{"deposit":"bdd604ba-f606-4617-a578-150ba2636ff5"},"_deposit":{"created_by":18,"id":"51477","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51477"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051477","sets":["2812:2813:4014"]},"author_link":["92917","2354"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-05-24","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"7p.","bibliographicVolumeNumber":"2018-04-01 - 2021-03-31","bibliographic_titles":[{"bibliographic_title":"令和2(2020)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2020 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"褐色脂肪細胞（BA）の体内時計の病態生理学的意義を明らかにするために、BA特異的に体内時計を欠損したマウスを作製した。このマウスでは、BAにおいて脂肪酸を利用した熱産生の障害が認められ、自発運動量の増加や骨格筋のふるえによる熱産生を増加させて代償的に体温を維持していた。また、エネルギー消費量が少なく、高脂肪食負荷時には肥満が増悪した。したがって、BAの体内時計は熱産生の制御に重要であり、肥満・生活習慣病の予防・治療標的となることが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"To elucidate the pathophysiological role of circadian clock in brown adipocytes (BA), BA-specific clock knockout mice were generated. This strain showed impairment of thermogenesis using fatty acids and maintained body temperature by increasing shivering and behavioral thermogenesis. Moreover, the conditional knockout mice exhibited reduced energy expenditure and were more prone to diet-induced obesity. These results reveal the importance of the BA clock for controlling thermogenesis and preventing/treating obesity and related diseases.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18K08470, 研究期間(年度):2018-04-01 - 2021-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「褐色脂肪細胞における熱産生リズムの形成機構解明と制御法の開発」研究成果報告書　課題番号18K08470\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K08470/18K08470seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057780","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50382875"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50382875","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K08470/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K08470/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K08470/18K08470seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K08470/18K08470seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-10"}],"displaytype":"detail","filename":"ME-PR-ANDO-H-kaken 2021-7p.pdf","filesize":[{"value":"723.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-ANDO-H-kaken 2021-7p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51477/files/ME-PR-ANDO-H-kaken 2021-7p.pdf"},"version_id":"dcf20bd9-c238-44b1-95ca-49f99598157a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"褐色脂肪細胞における熱産生リズムの形成機構解明と制御法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"褐色脂肪細胞における熱産生リズムの形成機構解明と制御法の開発"},{"subitem_title":"Elucidation of rhythm formation mechanism and treatment strategies of thermogenesis in brown adipocytes","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4014"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-10"},"publish_date":"2022-02-10","publish_status":"0","recid":"51477","relation_version_is_last":true,"title":["褐色脂肪細胞における熱産生リズムの形成機構解明と制御法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:51:05.180454+00:00"}