{"created":"2023-07-27T06:55:30.341612+00:00","id":51482,"links":{},"metadata":{"_buckets":{"deposit":"fd18a3e6-dd19-4acc-8ddb-6861ec0cfd8c"},"_deposit":{"created_by":18,"id":"51482","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51482"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051482","sets":["2812:2813:4014"]},"author_link":["85956","85957"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-04-22","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"7p.","bibliographicVolumeNumber":"2018-04-01 - 2021-03-31","bibliographic_titles":[{"bibliographic_title":"令和2(2020)年度 科学研究費補助金 若手研究 研究成果報告書"},{"bibliographic_title":"2020 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kobayashi, Tadahiro"}],"nameIdentifiers":[{"nameIdentifier":"85957","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20746383","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20746383"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では制御性B細胞が増加しているマウス（B細胞特異的PTEN欠損マウス）を用いて、制御性B細胞の悪性黒色腫に対する役割を解析した。B細胞特異的PTEN欠損マウスではコントロールマウスに比べて悪性黒色腫が増大し、腫瘍に浸潤する制御性B細胞も増加していた。腫瘍に浸潤する制御性B細胞の大部分はB1a B細胞であった。野生型マウスまたはIL-10欠損マウス由来のB1a B細胞を野生型マウスに移入したところ、野生型マウス由来のB1a B細胞を移入した群では腫瘍増生が増大した。以上より、腫瘍に浸潤したB1a B細胞はIL-10を産生することで悪性黒色腫に対する腫瘍免疫反応を抑制していると考えられた。","subitem_description_type":"Abstract"},{"subitem_description":"In tumor immunity, the participation of IL-10-producing regulatory B cells (Bregs), which play an important role in suppressing immune responses, is unclear. In this study, we demonstrated an increase in B16F10 melanoma growth in B cell-specific phosphatase and tensin homolog (PTEN)-deficient mice in which Bregs were expanded. The number of tumor-infiltrating Bregs significantly increased in B cell-specific PTEN-deficient mice. More than 50% of tumor-infiltrating B cells consisted of Bregs, predominantly CD19+CD5+CD43+ B1a Bregs, in both B cell-specific PTEN-deficient and control mice. Adoptive transfer of B1a B cells from WT mice, but not IL-10-/- mice, exacerbated B16F10 melanoma growth. The current study indicates that B1a Bregs negatively regulate anti-melanoma immunity by producing IL-10. Therefore, B1a Bregs can be a potentially novel target for immunotherapy of melanomas.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18K15269, 研究期間(年度):2018-04-01 - 2021-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「腫瘍免疫における制御性B細胞の役割および作用機序についての解析」研究成果報告書　課題番号18K15269\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K15269/18K15269seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院皮膚科","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057785","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20746383"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20746383","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K15269/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K15269/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K15269/18K15269seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K15269/18K15269seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小林, 忠弘"}],"nameIdentifiers":[{"nameIdentifier":"85956","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20746383","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20746383"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-10"}],"displaytype":"detail","filename":"HO-PR-KOBAYASHI-T-kaken 2021-7p.pdf","filesize":[{"value":"665.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-KOBAYASHI-T-kaken 2021-7p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51482/files/HO-PR-KOBAYASHI-T-kaken 2021-7p.pdf"},"version_id":"f964313b-f8c9-4784-8565-67e17c06bb08"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"腫瘍免疫における制御性B細胞の役割および作用機序についての解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"腫瘍免疫における制御性B細胞の役割および作用機序についての解析"},{"subitem_title":"Analysis of the role and mechanism of regulatory B cells in tumor immunity","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4014"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-10"},"publish_date":"2022-02-10","publish_status":"0","recid":"51482","relation_version_is_last":true,"title":["腫瘍免疫における制御性B細胞の役割および作用機序についての解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:22:09.946206+00:00"}