{"created":"2023-07-27T06:55:30.386580+00:00","id":51483,"links":{},"metadata":{"_buckets":{"deposit":"ff7a6389-5bf7-4e68-b15f-54ce5c0bd0e9"},"_deposit":{"created_by":18,"id":"51483","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51483"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051483","sets":["2812:2813:3929"]},"author_link":["87777","87778"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-21","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2018-04-01 - 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 若手研究 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"褥瘡の病態を、虚血再灌流傷害モデルで検討した。野生型と比してIFN-γ，IL-6欠損マウスでは組織障害が軽減したが、IL-4、IL-10、IL-17A欠損マウスでは差はなかった。IFN-γ，IL-6欠損マウスではiNOS、TNF-α、MCP-1等が低下していた。野生型マウスへのIFN-γ，IL-6抗体の経静脈的投与で潰瘍径が縮小した。マクロファージをIFN-γで刺激するとNO産生が増加した。IFN-γ，IL-6マウスでは，マクロファージの浸潤が減少，当初はM1分画優位で，後にM2分画が増加した。IFN-γ、IL-6等のサイトカインは虚血再灌流障害における組織障害と潰瘍の治癒に関与していた。","subitem_description_type":"Abstract"},{"subitem_description":"Ischemia-reperfusion (IR) is considered a key mechanism of pressure ulcer. The purpose of this study is to assess a role of cytokines and in the ulcer formation process using a cutaneous IR mouse model. Both IFN- gamma-deficient and IL-6-deficient mice that received IR cycles showed improvement of tissue damage. In these mutant mice, reduced macrophage infiltration and increased expression of iNOS, TNF-alfa and MCP-1 were observed. Wild type mice injected anti- IFN-gamma mAb or anti-IL-6 mAb intravenously showed improvement ulcer size. In vitro culture of macrophages from wild type mice stimulated with IFN- gamma resulted in increased production of NO. The ratio of M1 macrophages were more dominant in early phase of IR cycles at the wound site, whereas M2 macrophages ratio was gradually increased as time passes. This study indicates that IR injury is mediated by M1 and M2 macrophage infiltration that is induced by inflammatory cytokines including IFN-gamma and IL-6.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18K16021, 研究期間(年度):2018-04-01 - 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「皮膚虚血再灌流障害モデルにおけるサイトカインの役割の研究」研究成果報告書　課題番号18K16021\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K16021/18K16021seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057786","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10707079"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10707079","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K16021/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K16021/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K16021/18K16021seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K16021/18K16021seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-22"}],"displaytype":"detail","filename":"ME-PR-MAEDA-S-kaken 2020-4p.pdf","filesize":[{"value":"204.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MAEDA-S-kaken 2020-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51483/files/ME-PR-MAEDA-S-kaken 2020-4p.pdf"},"version_id":"a07faac0-71d6-4d7c-a67d-e8d95ff9273b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"皮膚虚血再灌流障害モデルにおけるサイトカインの役割の研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"皮膚虚血再灌流障害モデルにおけるサイトカインの役割の研究"},{"subitem_title":"A role of cytokine in a cutaneous ischemia-reperfusion injury model of mice","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-22"},"publish_date":"2021-04-22","publish_status":"0","recid":"51483","relation_version_is_last":true,"title":["皮膚虚血再灌流障害モデルにおけるサイトカインの役割の研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:04:19.270050+00:00"}