{"created":"2023-07-27T06:55:30.748987+00:00","id":51491,"links":{},"metadata":{"_buckets":{"deposit":"fe06cc67-5ad9-47fd-a9c5-dd212eb1baa6"},"_deposit":{"created_by":18,"id":"51491","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51491"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051491","sets":["2812:2813:4014"]},"author_link":["2209","74398"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-04-12","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"10p.","bibliographicVolumeNumber":"2019-06-28 - 2021-03-31","bibliographic_titles":[{"bibliographic_title":"令和2(2020)年度 科学研究費補助金 挑戦的研究(萌芽) 研究成果報告書"},{"bibliographic_title":"2020 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"前立腺がんにおいて10-30%程度の頻度で起こるRB1遺伝子領域のホモ型欠失にその近傍に位置するSUCLA2遺伝子が極めて頻繁に巻き込まれることが判った。SUCLA2をノックアウトすると実際に様々な代謝脆弱性が発現した。これは治療戦略上重要なアキレス腱となり得ると考えた。SUCLA2遺伝子欠失を標的とした化合物ライブラリーのスクリーニングを行い、いくつかのヒット化合物を得た 。このうちチモキノンの研究開発に注力し、構造展開と分子標的同定を行った。また、SUCLA2遺伝子欠失の診断法の開発とバイオマーカーの探索を目指した。","subitem_description_type":"Abstract"},{"subitem_description":"We discovered that the SUCLA2 gene located in the vicinity of RB1 is collaterally deleted together with RB1 with 10-30% prevalence in advanced prostate cancer. SUCLA2 gene encodes a metabolic enzyme constituting the a-subunit of the succinate CoA ligase heterodimer that reversibly converts succinyl CoA to succinate. We further found that SUCLA2 deficiency generates a certain metabolic vulnerability thus could be an important Achilles tendon in the treatment strategy. We screened chemical libraries to find compounds that specifically kill SUCLA2-deficient cells and obtained several hits. In this research, we focused on one of them thymoquinone. We performed structural development and molecular target identification. We also aimed to develop a diagnostic method for SUCLA2 gene deletion and search for biomarkers.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19K22555, 研究期間(年度):2019-06-28 - 2021-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「SUCLA2欠失によって生ずる代謝脆弱性を標的とする新規創薬研究」研究成果報告書　課題番号19K22555\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19K22555/19K22555seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057794","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん進展制御研究所"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50283619"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50283619","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22555/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22555/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19K22555/19K22555seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19K22555/19K22555seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-03"}],"displaytype":"detail","filename":"CA-PR-TAKAHASHI-C-kaken 2021-10p.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-TAKAHASHI-C-kaken 2021-10p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51491/files/CA-PR-TAKAHASHI-C-kaken 2021-10p.pdf"},"version_id":"05b14722-61d8-4993-ba13-d32b9f9296b7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"SUCLA2欠失によって生ずる代謝脆弱性を標的とする新規創薬研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"SUCLA2欠失によって生ずる代謝脆弱性を標的とする新規創薬研究"},{"subitem_title":"Drug development targeting metabolic vulnerability associated with SUCLA2 loss","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4014"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-03"},"publish_date":"2022-02-03","publish_status":"0","recid":"51491","relation_version_is_last":true,"title":["SUCLA2欠失によって生ずる代謝脆弱性を標的とする新規創薬研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:53:06.854034+00:00"}