{"created":"2023-07-27T06:55:30.932367+00:00","id":51496,"links":{},"metadata":{"_buckets":{"deposit":"88e08afa-4f44-49a5-977b-75418321e4f0"},"_deposit":{"created_by":18,"id":"51496","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51496"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051496","sets":["2812:2813:4014"]},"author_link":["88988","88989"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-05-29","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2018-04-01 – 2021-03-31","bibliographic_titles":[{"bibliographic_title":"令和2(2020)年度 科学研究費補助金 若手研究 研究成果報告書"},{"bibliographic_title":"2020 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"消化器癌術後において、感染性合併症により癌転移が促進されるという報告があるが、明確な機序は解明されていない。好中球細胞外トラップ（NETs）にcirculating tumor cellがトラップされ、活性化した血小板がさらに接着することで、血小板由来のMHC classⅠによって免疫担当細胞から自己と認識され免疫回避に寄与しているのではないかと考えた。\n腹腔内感染症モデルマウスにおいて、膵癌細胞は肝類洞内に活性化した血小板接着を伴いcluster形成し、核変形を認めずviableな状態で存在していることを証明し、この機序が癌転移形成におけるfirst stepになると考えた。","subitem_description_type":"Abstract"},{"subitem_description":"The impacts of postoperative abdominal infectious complications increase hematogenous distant metastasis and result in poor long term survival after curative resection. Even if curative resection can be performed, the presence of circulating tumor cells is affected. The liver, the most common site of metastases, is an important organ in innate immune surveillance. The purpose of this study was to identify the effect of platelets on escape from innate immune surveillance in postoperative abdominal infectious complications. In the infectious model, although epithelial cells without platelet adhesion were in an apoptotic state, mesenchymal cells showed many viable cancer cells surrounded by activated platelets. Mesenchymal cells could escape from immune surveillance by becoming surrounded by adhered activated platelets. We hypothesized that this mechanism would be the first step in cancer metastasis formation.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18K16302, 研究期間(年度):2018-04-01 – 2021-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「癌転移における好中球細胞外トラップ(NETs)の機能解析」研究成果報告書　課題番号18K16302\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K16302/18K16302seika/）を加工して作成\n","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057799","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院肝胆膵・移植外科"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50781126"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50781126","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K16302/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K16302/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K16302/18K16302seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K16302/18K16302seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-28"}],"displaytype":"detail","filename":"HO-PR-OKAZAKI-M-kaken 2021-5p.pdf","filesize":[{"value":"527.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-OKAZAKI-M-kaken 2021-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51496/files/HO-PR-OKAZAKI-M-kaken 2021-5p.pdf"},"version_id":"f8711772-c747-46d7-9733-857f1b9790a9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"癌転移における好中球細胞外トラップ(NETs)の機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"癌転移における好中球細胞外トラップ(NETs)の機能解析"},{"subitem_title":"The Role of Neutrophil Extracellular Traps (NETs) in Cancer Metastasis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4014"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-28"},"publish_date":"2022-02-28","publish_status":"0","recid":"51496","relation_version_is_last":true,"title":["癌転移における好中球細胞外トラップ(NETs)の機能解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:45:00.905746+00:00"}