{"created":"2023-07-27T06:55:31.340154+00:00","id":51505,"links":{},"metadata":{"_buckets":{"deposit":"59ea3e6f-b6a2-44f7-81f9-feb32b5f35b3"},"_deposit":{"created_by":18,"id":"51505","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51505"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051505","sets":["2812:2813:3929"]},"author_link":["67483"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-04-30","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2017-04-01 - 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"膵癌切除標本を用いて検討した結果、線維芽細胞上に老化蛋白(p16染色)の発現が散在性にみられ、さらにSASP因子(IL-6染色)の発現も認められ、SASPに至った老化線維芽細胞が存在することが確認された。培養線維芽細胞に対して，放射線照射による細胞老化を起こしたところ，SASPが誘導された。さらにSASPが誘導された線維芽細胞は，膵癌細胞の浸潤能，移動能および増殖能を有意に亢進させていた。","subitem_description_type":"Abstract"},{"subitem_description":"Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extensive desmoplastic stroma. It is known that senescent cancer stroma affects cancer progression through the senescence-associated secretory phenotype (SASP). Our aims is to assess whether SASP factor expression is associated with the prognosis of patients with PDAC. To examine the expression and localization of senescent stromal cells, we carried out an immunohistochemical analysis using anti- p16 and IL-6 antibodies. IL-6 expression was detected with the intensity being weak in 36 and strong in 29 specimens. Patients with strong IL-6 expression had significantly lower overall survival rates than those with weak IL-6 expression. The intensity of stromal IL-6 expression was also correlated positively to the stromal p16 expression at the same area. The association of IL-6 expression with clinical outcomes provide us with an understanding of the effect of senescent stroma on the prognosis of PDAC.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17K10693, 研究期間(年度):2017-04-01 - 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「膵癌組織内で構築される免疫寛容・転移促進の分子基盤の解明と新規治療法の開発」研究成果報告書　課題番号17K10693\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K10693/17K10693seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域保健学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057808","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40194170"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40194170","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K10693/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K10693/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K10693/17K10693seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K10693/17K10693seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-22"}],"displaytype":"detail","filename":"ME-PR-OHTA-T-kaken 2020-4p.pdf","filesize":[{"value":"216.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-OHTA-T-kaken 2020-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51505/files/ME-PR-OHTA-T-kaken 2020-4p.pdf"},"version_id":"d99b6a10-0278-4a11-bc21-722561181f8d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"膵癌組織内で構築される免疫寛容・転移促進の分子基盤の解明と新規治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"膵癌組織内で構築される免疫寛容・転移促進の分子基盤の解明と新規治療法の開発"},{"subitem_title":"The influence of senescent stroma on PDAC","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-22"},"publish_date":"2021-04-22","publish_status":"0","recid":"51505","relation_version_is_last":true,"title":["膵癌組織内で構築される免疫寛容・転移促進の分子基盤の解明と新規治療法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:04:16.290704+00:00"}