{"created":"2023-07-27T06:55:31.385759+00:00","id":51509,"links":{},"metadata":{"_buckets":{"deposit":"a4ac0f71-2a2d-44e9-a149-d93d0fc52967"},"_deposit":{"created_by":18,"id":"51509","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51509"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051509","sets":["2812:2813:4014"]},"author_link":["89051","89052"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-04-28","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2019-04-01 - 2021-03-31","bibliographic_titles":[{"bibliographic_title":"令和2(2020)年度 科学研究費補助金 若手研究 研究成果報告書"},{"bibliographic_title":"2020 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ラット心を低温単純浸漬法にて保存実験した．control群（n=6）として保存液のみ，AFGP添加群（n=6）として保存液にAFGP500μg/mLを添加したものを，それぞれ浸漬保存液として使用した．4℃，24時間の低温単純浸漬保存の後，Langendorff装置による再灌流実験を実施し，30分，60分，90分，120分経過時点の心拍数，冠灌流量，心収縮力，心拡張力を測定した．また，保存心の組織水分含有量と組織ATP含有量を測定し，それぞれの測定項目について2群間の結果を比較検討した．多くの項目において，AFGP添加群の保存心が運動機能的・代謝機能的に良い状態であったことが示された．","subitem_description_type":"Abstract"},{"subitem_description":"Surgically removed control rat hearts (n = 6) were immersed in UW solution while AFGP-treated hearts (AFGP group) (n = 6) were immersed in UW solution containing 500 μg/mL AFGP. After static hypothermic preservation, a Langendorff apparatus was used to reperfuse the coronary arteries. After 30, 60, 90, and 120 min the heart rate (HR), coronary flow (CF), cardiac contractile force (max dP/dt), and cardiac diastolic force (min dP/dt) were measured. Tissue water content (TWC) and tissue adenosine triphosphate (ATP) levels in the reperfused preserved hearts were also assessed. All parameters were compared between the control and AFGP groups.The higher HR, CF, max dP/dt, min dP/dt, and tissue ATP levels in the AFGP than control hearts suggested that AFGP conferred superior hemodynamic and metabolic functions. Thus, AFGP might be a useful additive for the static/nonfreezing hypothermic preservation of hearts.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19K18174, 研究期間(年度):2019-04-01 - 2021-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「微弱電磁場と不凍糖タンパクを用いた低温心保存法」研究成果報告書　課題番号19K18174\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19K18174/19K18174seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院心臓血管外科","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057812","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60619790"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60619790","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K18174/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K18174/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19K18174/19K18174seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19K18174/19K18174seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-17"}],"displaytype":"detail","filename":"HO-PR-TAKAGO-S-kaken 2021-5p.pdf","filesize":[{"value":"361.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-TAKAGO-S-kaken 2021-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51509/files/HO-PR-TAKAGO-S-kaken 2021-5p.pdf"},"version_id":"64834f21-8a81-4076-b6f0-9b312ba5cdb9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"微弱電磁場と不凍糖タンパクを用いた低温心保存法","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"微弱電磁場と不凍糖タンパクを用いた低温心保存法"},{"subitem_title":"Heart Cryopreservation using Antifreeze Glycoprotein in a Variable Magnetic Field","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4014"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-17"},"publish_date":"2022-02-17","publish_status":"0","recid":"51509","relation_version_is_last":true,"title":["微弱電磁場と不凍糖タンパクを用いた低温心保存法"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:50:47.186626+00:00"}