{"created":"2023-07-27T06:55:31.566152+00:00","id":51514,"links":{},"metadata":{"_buckets":{"deposit":"df27a58b-e73c-4fcb-9622-3e1c58b61825"},"_deposit":{"created_by":18,"id":"51514","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51514"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051514","sets":["2812:2813:4014"]},"author_link":["89061","89062"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-05-11","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2019-04-01 - 2021-03-31","bibliographic_titles":[{"bibliographic_title":"令和2(2020)年度 科学研究費補助金 若手研究 研究成果報告書"},{"bibliographic_title":"2020 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"EBV-LPD(EB virus-associated lymphoproliferative disorder)を発症した患者の全血におけるEBV-DNA copy数を定量的PCRで評価すると共にEBV-LPDを発症した患者と、EBVに関連しない悪性リンパ腫患者、健常人の3群間でKIR 遺伝子プロフィルを比較し、EBV-LPDとKIR遺伝子プロフィルの関係を検討した。結果EBV-LPDを発症した患者では、活性型KIRであるKIR2DS1、KIR2DS5、抑制型KIRである2DL5の保有率が有意に低値であった。患者のKIR 遺伝子プロフィルがEBV-LPDの発症に影響する可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"To identify the association between KIR gene polymorphisms and susceptibility to EBV-LPD (EB virus-associated lymphoproliferative disorder), we determined EBV copy numbers in the whole blood of patients suspected of having EBV-LPD using quantitative real-time PCR, and determined the KIR gene profile of these patients as well as those who develop non-EBV associated lymphoma and healthy individuals using PCR with specific primers. In patients with EBV-LPD, the frequencies of KIR2DS1, 2DS5 and 2DL5 were significantly lower than those in healthy individuals and non-EBV associated lymphoma. The result suggests that the KIR gene repertoire may be associated with susceptibility to EBV-LPD.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19K17825, 研究期間(年度):2019-04-01 - 2021-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「EBV関連リンパ増殖性疾患発症とKIRの関連」研究成果報告書　課題番号19K17825\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19K17825/19K17825seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057817","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10825706"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10825706","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K17825/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K17825/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19K17825/19K17825seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19K17825/19K17825seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-17"}],"displaytype":"detail","filename":"ME-PR-IWAKI-N-kaken 2021-5p.pdf","filesize":[{"value":"248.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-IWAKI-N-kaken 2021-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51514/files/ME-PR-IWAKI-N-kaken 2021-5p.pdf"},"version_id":"1804a633-b6c5-449c-a566-907f9e139bd3"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"EBV関連リンパ増殖性疾患発症とKIRの関連","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"EBV関連リンパ増殖性疾患発症とKIRの関連"},{"subitem_title":"Association of KIR genotype profile on the development of EBV-related iatrogenic immunodeficiency-associated lymphoproliferative disorders","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4014"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-17"},"publish_date":"2022-02-17","publish_status":"0","recid":"51514","relation_version_is_last":true,"title":["EBV関連リンパ増殖性疾患発症とKIRの関連"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:50:43.237626+00:00"}