{"created":"2023-07-27T06:55:32.438862+00:00","id":51563,"links":{},"metadata":{"_buckets":{"deposit":"93616a0e-6daa-4b48-8f1c-70ed652ae612"},"_deposit":{"created_by":18,"id":"51563","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51563"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051563","sets":["2812:2813:3929"]},"author_link":["93006","80505"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-25","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2017-04-01 - 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"腫瘍の画像診断とホウ素中性子捕捉療法の融合を目的として、σ-2受容体に高い親和性と選択性をもつホウ素含有イメージング剤の開発研究を行った。様々なvesamicol類縁体のデザインと有機化学合成、in vitroスクリーニングを行い、σ受容体に高い親和性を示したホウ素含有化合物とヒト悪性黒色腫A375細胞を用い、in vitro薬物細胞内取り込み実験を行ったが、残念ながら全てのサンプルにおいてホウ素の含有量は10 ng/mL未満であった。しかしながら、limonene骨格を有する新規化合物がσ-1受容体と比べて14倍以上という高いσ-2受容体選択性を示すことを見出した。","subitem_description_type":"Abstract"},{"subitem_description":"For the purpose of the fusion of tumor image diagnosis and the boron neutron capture therapy, I had studied the development of the boron-containing imaging agent to have high affinity and selectivity to σ-2 receptor. Various new designed vesamicol relatives showed high affinity to σ receptor in in vitro screening. The boron-containing compound were performed the in vitro cellular uptake test using human malignant melanoma A375 cells, but the content of boron in all samples were 10 ng/mL. However, I found that new compounds having limonene frame showed 14 times more σ-2 receptor affinity than σ-1 receptor affinity.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17K10355, 研究期間(年度):2017-04-01 - 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「固形腫瘍の画像診断及びホウ素中性子捕捉療法を目的としたσ-2受容体標的薬剤の開発」研究成果報告書　課題番号17K10355\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K10355/17K10355seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学学際科学実験センターアイソトープ総合研究施設","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057866","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50579836"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50579836","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K10355/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K10355/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K10355/17K10355seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K10355/17K10355seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-22"}],"displaytype":"detail","filename":"FR-PR-KOZAKA-T-kaken 2020-6p.pdf","filesize":[{"value":"175.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"FR-PR-KOZAKA-T-kaken 2020-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51563/files/FR-PR-KOZAKA-T-kaken 2020-6p.pdf"},"version_id":"879fe9e6-9296-4127-940b-1655e98c0fe5"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"固形腫瘍の画像診断及びホウ素中性子捕捉療法を目的としたσ-2受容体標的薬剤の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"固形腫瘍の画像診断及びホウ素中性子捕捉療法を目的としたσ-2受容体標的薬剤の開発"},{"subitem_title":"Development of a new sigma-2 receptor ligand for imaging and BNCT","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-22"},"publish_date":"2021-04-22","publish_status":"0","recid":"51563","relation_version_is_last":true,"title":["固形腫瘍の画像診断及びホウ素中性子捕捉療法を目的としたσ-2受容体標的薬剤の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:04:09.504621+00:00"}