{"created":"2023-07-27T06:55:32.768192+00:00","id":51574,"links":{},"metadata":{"_buckets":{"deposit":"08c61107-2b3a-4f2b-a1bc-890be0db3660"},"_deposit":{"created_by":18,"id":"51574","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51574"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051574","sets":["2812:2813:3929"]},"author_link":["83250","83238"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-14","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2014-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"患者への侵襲が少なく、繰り返し経時的に評価できるリキッドバイオプシーによる新規泌尿器癌転移バイオマーカーの開発を試みた。hTERTプロモーターとGFPを組み込んだ新規adenovirusベクターを用いたシステムを使用して、血液中に混注した癌細胞を同定することが可能であった。しかし、検出するためには血液1ml中に100-1000個の癌細胞が必要であり、精度は低いものであった。一方、ヒト前立腺癌細胞株を使用したexosomeに内包されたmicro RNA の解析では、複数の候補の中からmiR124が転移性去勢抵抗性前立腺癌の増悪に関与する可能性が示唆された","subitem_description_type":"Abstract"},{"subitem_description":"We tried to find out a novel metastatic biomarkers of urological cancers using liquid biopsy as a repeatable and less invasive method. Adenovirus vector with GFP and hTERT promotor could detect cancer cells mixed in human blood samples; however, it needed more than 100 cells /ml to detect them, indicating low paformance for clinical use as it was. Micro RNA analysis in exosome from supernatant of protate cancer cells reveled that miR124 might contribute to metastasis of castration-resistant prostate cancer.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17K11127, 研究期間(年度):2014-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「新規末梢血癌細胞検出法を応用した泌尿器癌転移に関するバイオマーカーの開発」研究成果報告書　課題番号17K11127\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K11127/17K11127seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057877","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00452102"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00452102","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K11127/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K11127/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K11127/17K11127seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K11127/17K11127seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-22"}],"displaytype":"detail","filename":"ME-PR-KITAGAWA-Y-kaken 2020-5p.pdf","filesize":[{"value":"134.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KITAGAWA-Y-kaken 2020-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51574/files/ME-PR-KITAGAWA-Y-kaken 2020-5p.pdf"},"version_id":"c1ec44e4-d183-420c-989b-4a8fdf703a0c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"新規末梢血癌細胞検出法を応用した泌尿器癌転移に関するバイオマーカーの開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規末梢血癌細胞検出法を応用した泌尿器癌転移に関するバイオマーカーの開発"},{"subitem_title":"Depelopment of novel biokarker in metastasis of urological cancer using a novel circulating tumor cell detector system","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-22"},"publish_date":"2021-04-22","publish_status":"0","recid":"51574","relation_version_is_last":true,"title":["新規末梢血癌細胞検出法を応用した泌尿器癌転移に関するバイオマーカーの開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:03:56.741384+00:00"}