{"created":"2023-07-27T06:55:33.131578+00:00","id":51584,"links":{},"metadata":{"_buckets":{"deposit":"7f4d7064-4f84-467a-98c0-6493715b330f"},"_deposit":{"created_by":18,"id":"51584","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51584"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051584","sets":["2812:2813:4014"]},"author_link":["78854","93032"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-06-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"10p.","bibliographicVolumeNumber":"2018-04-01 - 2021-03-31","bibliographic_titles":[{"bibliographic_title":"令和2(2020)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2020 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"マラリアは年間２億人の患者と40万人以上の死者を出す世界的な感染症である。効果的なマラリアワクチンの開発が求められる一方、現在までにその実用化には至っていない。本研究では、組換えウイルスを利用したマラリアワクチンの開発を行なった。独自に作製したワクチンを用いて動物実験を行なったところ、２回の接種のみで80％以上のマウスでマラリア感染防御効果（＝全く感染しない）を得ることに成功した。これらのワクチン接種されたマウスでマラリア原虫に対する免疫応答の誘導を確認するとともに、ワクチンの実用化に向け最適な精製方法や保管方法の検討も行われた。","subitem_description_type":"Abstract"},{"subitem_description":"Malaria is a global infectious disease that causes 200 million patients and more than 400,000 deaths annually. While the development of an effective malaria vaccine is required, a completely effective vaccine is not yet available. In this study, we developed a malaria vaccine based on recombinant viruses. When animal experiments were conducted using the vaccine that was originally prepared, we obtained sterile protection effect, which means no infection at all, for 80% of mice or more with only two-dose administration. Induction of an immune response against Plasmodium parasites was confirmed in vaccinated animals, and the optimum purification method and storage method for practical use of the vaccine were also examined.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18K06655, 研究期間(年度):2018-04-01 - 2021-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「ヘテロローガス・プライムブースト免疫法を用いた新規ワクチンプラットフォームの開発」研究成果報告書　課題番号18K06655\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K06655/18K06655seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057887","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20608351"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20608351","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K06655/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K06655/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K06655/18K06655seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K06655/18K06655seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-17"}],"displaytype":"detail","filename":"PH-PR-IYORI-M-kaken 2021-10p.pdf","filesize":[{"value":"176.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-IYORI-M-kaken 2021-10p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51584/files/PH-PR-IYORI-M-kaken 2021-10p.pdf"},"version_id":"34fbd253-0a80-45c3-a228-b9f984953509"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ヘテロローガス・プライムブースト免疫法を用いた新規ワクチンプラットフォームの開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヘテロローガス・プライムブースト免疫法を用いた新規ワクチンプラットフォームの開発"},{"subitem_title":"The development of a novel vaccine vector by the heterologous prime-boost immunization regimen","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4014"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-17"},"publish_date":"2022-02-17","publish_status":"0","recid":"51584","relation_version_is_last":true,"title":["ヘテロローガス・プライムブースト免疫法を用いた新規ワクチンプラットフォームの開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:50:33.244463+00:00"}