{"created":"2023-07-27T06:55:33.222133+00:00","id":51586,"links":{},"metadata":{"_buckets":{"deposit":"e8e7fedc-588a-47e8-83de-a1da39109731"},"_deposit":{"created_by":18,"id":"51586","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51586"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051586","sets":["2812:2813:3929"]},"author_link":["78856","78857"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-09-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"11p.","bibliographicVolumeNumber":"2018-06-29 - 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 挑戦的研究(萌芽) 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"バキュロウイルス(BV)筋注により誘導された自然免疫応答が肝臓期マラリア原虫を排除していることをIFN-aRKOおよびIFN-gRKOマウスを用いて解明した。プリマキンでは、感染24時間後の肝臓内原虫を排除することはできず、BV効果がプリマキンを上回っていることが明らかとなった。このメカニズムとして、BVが誘導する抗肝臓期マラリア原虫活性はIFN- aからのシグナル伝達による自然免疫応答メカニズムが大きく関与することが明らかとなった","subitem_description_type":"Abstract"},{"subitem_description":"Baculovirus (BV)-induced innate immunity completely kills liver-stage　parasites using IFN-aRKO and IFN-gRKO mice. As primaquine (PQ) is the only licensed drug for the radical cure of P. vivax hypnozoites, we compared the elimination effects of BV with those of PQ. Treatment with PQ could not exclude liver-stage　parasites. Treatment with BV proves to be more effective than PQ. BV effectively induces fast-acting innate immune responses that provide powerful first lines of both defensive and offensive attacks against pre-erythrocytic parasites. Our results illustrate the potential of BV as a new potent prophylactic and therapeutic immunostimulatory agent against pre-erythrocytic stage parasites.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18K19394, 研究期間(年度):2018-06-29 - 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「プリマキンに替わる抗マラリア自然免疫賦活化薬の開発」研究成果報告書　課題番号18K19394\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K19394/18K19394seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057889","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10296121"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10296121","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K19394/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K19394/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K19394/18K19394seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K19394/18K19394seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-22"}],"displaytype":"detail","filename":"PH-PR-YOSHIDA-S-kaken 2020-11p.pdf","filesize":[{"value":"155.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-YOSHIDA-S-kaken 2020-11p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51586/files/PH-PR-YOSHIDA-S-kaken 2020-11p.pdf"},"version_id":"5619215a-568a-41b0-ba46-03d7f738e0bc"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"プリマキンに替わる抗マラリア自然免疫賦活化薬の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"プリマキンに替わる抗マラリア自然免疫賦活化薬の開発"},{"subitem_title":"Development of a new immunostimulatory drug for non-haemolytic alternative to PQ","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-22"},"publish_date":"2021-04-22","publish_status":"0","recid":"51586","relation_version_is_last":true,"title":["プリマキンに替わる抗マラリア自然免疫賦活化薬の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:03:47.748318+00:00"}