{"created":"2023-07-27T06:55:34.543748+00:00","id":51628,"links":{},"metadata":{"_buckets":{"deposit":"141a6f3d-33f7-4c01-aaa1-9c1662829461"},"_deposit":{"created_by":18,"id":"51628","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51628"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051628","sets":["2812:2813:4014"]},"author_link":["74241"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-06-01","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2018-04-01 - 2021-03-31","bibliographic_titles":[{"bibliographic_title":"令和2(2020)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2020 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"肝細胞がんにおいて、腫瘍細胞と間質細胞が協調相互作用し、様々な内外ストレスに順応するがんエコシステムを形成し対応していると考えられている。網羅的遺伝子発現データから、がんエコシステム形成に中心的な役割を示す肝がん幹細胞が、ケモカインCCL20を高発現している事を見出した。CCL20高発現は、肝がん患者の予後不良因子であった。肝がん幹細胞から分泌されるCCL20は、CCR6陽性免疫細胞誘導を介したがんエコシステム構築に関連していた。CCL20-CCR6軸を標的としたCCL20中和抗体療法は、がんエコシステムを変容する事で良好な腫瘍増殖抑制効果を示した。","subitem_description_type":"Abstract"},{"subitem_description":"In hepatocellular carcinoma (HCC), tumor cells and stromal cells are thought to interact cooperatively to form a cancer ecosystem that adapts to various internal and external stresses. From comprehensive gene expression data, we found that liver cancer stem cells, which play a central role in the formation of the cancer ecosystem, highly express the chemokine CCL20. We also found that high expression of CCL20 is a poor prognostic factor for HCC patients. CCL20 secreted by liver cancer stem cells was associated with the establishment of the cancer ecosystem through the induction of CCR6-positive immune cells. Finally, CCL20 neutralizing antibody therapy targeting the CCL20-CCR6 axis showed favorable tumor growth inhibition by altering the cancer ecosystem.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18K07998, 研究期間(年度):2018-04-01 - 2021-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「肝がんのがんエコシステム解析に基づく新規治療標的分子探索」研究成果報告書　課題番号18K07998\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K07998/18K07998seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学先進予防医学研究センター","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057931","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30334783"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30334783","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07998/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07998/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K07998/18K07998seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K07998/18K07998seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-17"}],"displaytype":"detail","filename":"ME-PR-YAMASHITA-T-kaken 2021-5p.pdf","filesize":[{"value":"74.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-YAMASHITA-T-kaken 2021-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51628/files/ME-PR-YAMASHITA-T-kaken 2021-5p.pdf"},"version_id":"57d8927d-8aff-4bc3-aa83-a6857e7c4aa4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肝がんのがんエコシステム解析に基づく新規治療標的分子探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝がんのがんエコシステム解析に基づく新規治療標的分子探索"},{"subitem_title":"Search for novel therapeutic target molecules based on the analysis of cancer ecosystem in liver cancer","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4014"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-17"},"publish_date":"2022-02-17","publish_status":"0","recid":"51628","relation_version_is_last":true,"title":["肝がんのがんエコシステム解析に基づく新規治療標的分子探索"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:50:24.841555+00:00"}