{"created":"2023-07-27T06:55:34.633323+00:00","id":51630,"links":{},"metadata":{"_buckets":{"deposit":"9751a3ee-06a0-4553-82de-cb3709d442f8"},"_deposit":{"created_by":18,"id":"51630","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51630"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051630","sets":["2812:2813:3929"]},"author_link":["501","85291"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-04-30","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2017-04-01 - 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"高齢者ブレインバンクから33例の剖検症例の硬膜を収集し、それらの硬膜をアミロイドbeta蛋白質（Abeta）に対する抗体（4G8）を用いて免疫染色を行なったところ、8例（24.2%）で硬膜上の血管にAbetaの沈着を認めた。収集した硬膜をホモジネートし、若年（3ヶ月齢）のAlzheimer病（AD）モデルマウスの脳に接種したところ、接種12ヶ月後にはAbeta沈着を認めた硬膜を接種したADモデルマウスでは脳血管にAbetaの沈着（脳アミロイドアンギオパチー：CAA）を認めたが、Abetaが沈着していなかった硬膜を接種したADモデルマウスでは脳実質および脳血管共にAbetaの沈着を認めなかった。","subitem_description_type":"Abstract"},{"subitem_description":"We obtained dura maters from 33 autopsied patients from a geriatric brain bank, and immunohistochemical study of those dura maters were performed using an antibody against amyloid beta protein (Abeta). Eight of 33 patients (24.2%) had Abeta deposition on the vessel of the dura mater. The dura maters were homogenized at 19% (w/v) in PBS, and the supernatants were injected into the brain of Alzheimer’s disease (AD) model mice. One year after the injection, immunohistochemical study using the antibody against Abeta showed that Abeta deposited on the vessels of AD model mice brain injected the homogenate of dura mater with Abeta deposition, while no Abeta deposition was observed in the brain and vessels of AD model mice injected the homogenate of dura mater without Abeta deposition.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17K09752, 研究期間(年度):2017-04-01 - 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「モデルマウスを用いた硬膜移植による脳βアミロイドーシスの個体間伝播についての研究」研究成果報告書　課題番号17K09752\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K09752/17K09752seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院脳神経内科","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057933","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70452109"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70452109","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K09752/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K09752/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K09752/17K09752seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K09752/17K09752seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-22"}],"displaytype":"detail","filename":"HO-PR-HAMAGUCHI-T-kaken 2020-5p.pdf","filesize":[{"value":"104.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-HAMAGUCHI-T-kaken 2020-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51630/files/HO-PR-HAMAGUCHI-T-kaken 2020-5p.pdf"},"version_id":"daf1febd-f18b-497e-9ca5-ebbebb511f16"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"モデルマウスを用いた硬膜移植による脳βアミロイドーシスの個体間伝播についての研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"モデルマウスを用いた硬膜移植による脳βアミロイドーシスの個体間伝播についての研究"},{"subitem_title":"A study on transmission of cerebral beta-amyloidosis via dura mater grafting using Alzheimer's disease model mice","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-22"},"publish_date":"2021-04-22","publish_status":"0","recid":"51630","relation_version_is_last":true,"title":["モデルマウスを用いた硬膜移植による脳βアミロイドーシスの個体間伝播についての研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:05:18.568031+00:00"}