{"created":"2023-07-27T06:55:34.678469+00:00","id":51631,"links":{},"metadata":{"_buckets":{"deposit":"313ed560-50ef-44e3-ad3a-74c7cb651930"},"_deposit":{"created_by":18,"id":"51631","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51631"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051631","sets":["2812:2813:3929"]},"author_link":["70283"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-22","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"8p.","bibliographicVolumeNumber":"2017-04-01 - 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"線維化は臓器障害に対する過度の創傷治癒反応、すなわち細胞外基質沈着と細胞外基質産生能を有する細胞の集積を特徴とする。近年、末期腎不全の予備軍として慢性腎臓病(CKD)が注目されている。このCKDが進展し腎不全に至る過程において、各種腎疾患は腎間質線維化という共通のプロセスをとることを特徴とする。本研究では、細胞骨格依存性シグナルが、腎固有細胞の生物学的特性を調節することで腎間質線維化にはたす意義の解明を試みた。その結果、腎固有細胞でのTGF-bシグナルによる細胞骨格依存性シグナルが、筋線維芽細胞分化を誘導することで、腎間質線維化進展に寄与することを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"Fibrosis is characterized by an excessive wound healing response to organ damage, causing extracellular matrix deposition and accumulation of fibroblasts/myofibroblasts. Recently, chronic kidney disease (CKD) has been thought as being at risk of developing end-stage renal disease. In the process of CKD progression to renal failure, various renal diseases are characterized by taking a common process which is renal interstitial fibrosis. In this study, we attempted to elucidate the significance of cytoskeleton-dependent signals for renal interstitial fibrosis by regulating the biological properties of renal resident cells. As a result, it was revealed that the cytoskeleton-dependent signal by TGF-b1 in renal resident cells contributes to the progression of renal interstitial fibrosis by inducing myofibroblast differentiation.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17K09691, 研究期間(年度):2017-04-01 - 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「細胞骨格依存性シグナルの腎線維化にはたす意義」研究成果報告書　課題番号17K09691\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K09691/17K09691seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院血液浄化療法部","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057934","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60377421"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60377421","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K09691/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K09691/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K09691/17K09691seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K09691/17K09691seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-22"}],"displaytype":"detail","filename":"HO-PR-SAKAI-N-kaken 2020-8p.pdf","filesize":[{"value":"220.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-SAKAI-N-kaken 2020-8p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51631/files/HO-PR-SAKAI-N-kaken 2020-8p.pdf"},"version_id":"19e977d1-60ba-4c7c-a50b-63da80c0c6fb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"細胞骨格依存性シグナルの腎線維化にはたす意義","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"細胞骨格依存性シグナルの腎線維化にはたす意義"},{"subitem_title":"Involvement of cytoskeleton-dependent signaling in renal fibrosis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-22"},"publish_date":"2021-04-22","publish_status":"0","recid":"51631","relation_version_is_last":true,"title":["細胞骨格依存性シグナルの腎線維化にはたす意義"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:05:19.991570+00:00"}