{"created":"2023-07-27T06:55:34.815670+00:00","id":51636,"links":{},"metadata":{"_buckets":{"deposit":"23188484-3aca-4845-a977-9bf7225bc3e2"},"_deposit":{"created_by":18,"id":"51636","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51636"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051636","sets":["2812:2813:3929"]},"author_link":["94074","94073"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-26","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2017-04-01 - 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"１背景:閉経前の乳癌患者に投与するタモキシフェン(TAM)には卵巣過剰刺激作用があることが以前より報告されており、我々も我が国でも強く現れることを報告した。また、TAM投与下の子宮内膜は、直接刺激にて子宮体癌の誘発のみならず、子宮の胚受容性の低下、不妊症を誘導する、との仮説を立てた。2目的：TAMによる卵巣過剰刺激、子宮内膜に対する作用機序を解析し、対策案を立てること。3方法:後方視的、前方視的に多施設にて調査、解析。4成果：卵巣過剰刺激についてTAM投与方法(Gn-RHa併用、化学療法後）や年齢による出現率や出現パターンの違い、TAM投与による内膜異常が半数近くに出現することを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"１Background:Tamoxifen (TAM), the hormone therapy for premenopausal breast cancer patients, has been previously reported to have ovarian hyperstimulation. We have previously reported that among Japanese young women with breast cancer, ovarian stimulation by TAM is strongly present. In addition, the idea is that the endometrium under TAM administration is directly stimulated by TAM, which not only induces endometrial cancer but also induces a new pathological condition of infertility. 2 Purpose: Analyzing the mechanism of action of ovarian hyperstimulation and endometrium change by TAM. 3Method: Retrospective and prospective view of ovarian hyperstimulation and the thickening and abnormality (polyp,Swiss-cheeselike )of the endometrium.4Result:The incidence and pattern of ovarian hyperstimulation by TAM administration method (Gn-RHa combination, after chemotherapy) and age were clarified. It was clarified that endometrial abnormalities due to TAM administration appeared in almost half.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17K11223, 研究期間(年度):2017-04-01 - 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「乳癌患者におけるタモキシフェン投与の子宮内膜着床能に及ぼす影響と作用機序の解析」研究成果報告書　課題番号17K11223\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K11223/17K11223seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院周産母子センター","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057939","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80507062"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80507062","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K11223/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K11223/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K11223/17K11223seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K11223/17K11223seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-22"}],"displaytype":"detail","filename":"HO-PR-YAMAZAKI-R-kaken 2020-5p.pdf","filesize":[{"value":"267.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-YAMAZAKI-R-kaken 2020-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51636/files/HO-PR-YAMAZAKI-R-kaken 2020-5p.pdf"},"version_id":"be8ee25f-8399-4a13-8bde-2997899f5925"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"乳癌患者におけるタモキシフェン投与の子宮内膜着床能に及ぼす影響と作用機序の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"乳癌患者におけるタモキシフェン投与の子宮内膜着床能に及ぼす影響と作用機序の解析"},{"subitem_title":"Effect of tamoxifen administration on endometrial implantation in breast cancer patients and analysis of its mechanism of action","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-22"},"publish_date":"2021-04-22","publish_status":"0","recid":"51636","relation_version_is_last":true,"title":["乳癌患者におけるタモキシフェン投与の子宮内膜着床能に及ぼす影響と作用機序の解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:05:22.793925+00:00"}