{"created":"2023-07-27T06:55:34.907773+00:00","id":51638,"links":{},"metadata":{"_buckets":{"deposit":"06def7fb-2d7b-4b1c-b614-be86fde08065"},"_deposit":{"created_by":18,"id":"51638","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51638"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051638","sets":["2812:2813:3929"]},"author_link":["70371","337"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-04-21","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"12p.","bibliographicVolumeNumber":"2017-04-01 - 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"慢性肝疾患は、重篤な合併症を伴う肝硬変状態に至る。これまでに我々は、多分化能および免疫修飾機能を有する間葉系幹細胞について、その投与による肝炎、肝硬変に対する治療の可能性を示してきた。本研究では、肝疾患状態にある成体の脂肪組織由来間葉系幹細胞、間質細胞の特性を解析することを目的に、動脈硬化高脂肪食（AT-HF)給餌によるNASH・肝硬変マウスモデル、および単純性脂肪肝(SS)マウスモデル（給餌後4週、12週後）より脂肪組織由来間質細胞群を経時的に採取し、非培養の細胞の幹細胞関連の抗原の発現、遺伝子発現プロファイルを解析した。慢性肝疾患状態における脂肪組織由来間質細胞特性の基礎データを獲得した。","subitem_description_type":"Abstract"},{"subitem_description":"Chronic liver diseases ultimately lead to liver cirrhosis. We previously demonstrated that mesenchymal stem cells, which are pluripotent and immunomodulatory, are possibly therapeutic for hepatitis/cirrhosis when they are administered. In the current study, aiming that analysis of characteristics of adipose tisse-derived mesenchymal stem cells, and stromal cells in murine host with chronic liver disease, we obtained adipose tissue-derived stromal cells crhonologically from non-alcoholic steatohepatitis/cirrhosis murine models fed by atherogenic high-fat diet, as well as simple steatosis murine model, and analyzed sten cell-related surface antigens expressions of uncultured cells as well as gene expression profile. By these experiments, we obtained that fundamental data of chracteristics of adipose tissue-derived stromal cells of the host with chronic liver diseases.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17K09413, 研究期間(年度):2017-04-01 - 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「慢性肝疾患の生体から獲得される脂肪組織由来間葉系幹細胞の肝修復再生能解析」研究成果報告書　課題番号17K09413\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K09413/17K09413seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057941","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80401925"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80401925","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K09413/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K09413/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K09413/17K09413seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K09413/17K09413seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-22"}],"displaytype":"detail","filename":"ME-PR-SAKAI-Y-kaken 2020-12p.pdf","filesize":[{"value":"96.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SAKAI-Y-kaken 2020-12p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51638/files/ME-PR-SAKAI-Y-kaken 2020-12p.pdf"},"version_id":"e9f55d8e-bb75-4237-9a9b-bd2329a02c42"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"慢性肝疾患の生体から獲得される脂肪組織由来間葉系幹細胞の肝修復再生能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"慢性肝疾患の生体から獲得される脂肪組織由来間葉系幹細胞の肝修復再生能解析"},{"subitem_title":"Analysis of liver repairing and regenerative capability of adipose tissue-derived stem cells obtained from the host with chronic liver disease","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-22"},"publish_date":"2021-04-22","publish_status":"0","recid":"51638","relation_version_is_last":true,"title":["慢性肝疾患の生体から獲得される脂肪組織由来間葉系幹細胞の肝修復再生能解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:05:24.389398+00:00"}