{"created":"2023-07-27T06:55:35.549076+00:00","id":51658,"links":{},"metadata":{"_buckets":{"deposit":"4d006b7b-60f9-4202-8ffa-ac6db0563ee8"},"_deposit":{"created_by":18,"id":"51658","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51658"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051658","sets":["2812:2813:4085"]},"author_link":["76757","259"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-19","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"10p.","bibliographicVolumeNumber":"2019-04-01 - 2022-03-31","bibliographic_titles":[{"bibliographic_title":"令和3(2021)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2021 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We have previously shown that vasopressin (AVP)-producing neurons are crucial for the central clock function of the suprachiasmatic nucleus (SCN). In this study, we further analyzed the function of AVP neurons. The results showed that (1) GABA released from SCN AVP neurons limits the neural activity of the SCN to the appropriate time frame on the SCN molecular clock so that mouse behavior occurs at the appropriate time, (2) AVP neurons regulate the period of rhythms of VIP and other SCN neurons to function as the primary pacemaker cells of the SCN neural network, and (3) AVP neurons in the hypothalamic paraventricular nucleus prominently promote wakefulness.","subitem_description_type":"Abstract"},{"subitem_description":"これまでに、視交叉上核（SCN）の中枢時計機能にバソプレシン（AVP）産生ニューロンが極めて重要なことを明らかにしてきた。本研究ではさらにAVPニューロンを中心に機能解析を進めた。その結果、①SCN AVPニューロンから放出されるGABAにより、SCNの分子時計上の適切な時間枠にSCNの神経活動が限定され、マウスの行動が適切な時間帯に起きること、②AVPニューロンはVIPニューロンや他のSCNニューロンのリズム周期を制御して、SCN神経ネットワークの主要なペースメーカー細胞として機能すること、③視床下部室傍核のAVPニューロンは強力な覚醒亢進作用を持つこと、等が明らかになった。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19H03399, 研究期間(年度):2019-04-01 - 2022-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「バソプレシン産生ニューロンを基軸とする中枢時計神経メカニズムの解明」課題番号19H03399\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19H03399/19H03399seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057961","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20296552"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20296552","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03399/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03399/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19H03399/19H03399seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-19H03399/19H03399seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-06"}],"displaytype":"detail","filename":"ME-PR-MIEDA-M-kaken 2022-10p.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MIEDA-M-kaken 2022-10p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51658/files/ME-PR-MIEDA-M-kaken 2022-10p.pdf"},"version_id":"4871cc4f-6834-4d62-8db8-4d1707c6a4e3"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"バソプレシン産生ニューロンを基軸とする中枢時計神経メカニズムの解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"バソプレシン産生ニューロンを基軸とする中枢時計神経メカニズムの解明"},{"subitem_title":"Understanding the roles of vasopressin neurons in the neural network of the central circadian clock","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4085"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-02-06"},"publish_date":"2023-02-06","publish_status":"0","recid":"51658","relation_version_is_last":true,"title":["バソプレシン産生ニューロンを基軸とする中枢時計神経メカニズムの解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:38:06.755523+00:00"}