{"created":"2023-07-27T06:55:35.641988+00:00","id":51660,"links":{},"metadata":{"_buckets":{"deposit":"9b675784-7d1b-4121-af69-4623a447d21a"},"_deposit":{"created_by":18,"id":"51660","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51660"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051660","sets":["2812:2813:3929"]},"author_link":["174","76763"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-18","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"7p.","bibliographicVolumeNumber":"2017-04-01 - 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"細胞膜に存在するホスファチジルイノシトール（PI）は脂質リン酸化酵素PI3キナーゼにより種々の3’-ホスホイノシチド（3’-PI）に変換され、細胞内小胞輸送やシグナル伝達に関与する。Myotubularin-related protein (MTMR）ファミリーはPI-3リン酸（PI(3)P）をPIへと変換する3’-PIホスファターゼである。本研究課題では、MTMR4が肺組織において II型肺胞上皮細胞（AECII）に高発現し、エンドソーム～リソソーム（エンドリソソーム）、オートファゴソームといった細胞内クリアランスを担う小器官の機能調節に重要な役割を果たすことを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"Phosphatidylinositol 3-phosphate (PI(3)P) is the predominant phosphoinositide species in early endosomes and autophagosomes, in which PI(3)P dictates traffic of these organelles. Phosphoinositide levels are tightly regulated by lipid-kinases and-phosphatases; however, a phosphatase that converts PI(3)P back to phosphatidylinositol in the endosomal and autophagosomal compartments is not fully understood. We investigated the subcellular distribution and functions of myotubularin-related protein-4 (MTMR4), which is distinct among other MTMRs in that it possesses a PI(3)P-binding FYVE domain, in lung alveolar epithelial cells. MTMR4 knockdown markedly suppressed the motility, fusion, and fission of PI(3)P-enriched structures, resulting in decreases in late endosomes, autophagosomes, and lysosomes. This project has unveiled that MTMR4 is essential for the integrity of endocytic and autophagic pathways.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17K08532, 研究期間(年度):2017-04-01 - 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「膜動現象を制御するイノシトールリン脂質脱リン酸化酵素の肺発達・成熟における役割」研究成果報告書　課題番号17K08532\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K08532/17K08532seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057963","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80333368"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80333368","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K08532/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K08532/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K08532/17K08532seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K08532/17K08532seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-26"}],"displaytype":"detail","filename":"ME-PR-YOSHIOKA-K-kaken 2020-7p.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-YOSHIOKA-K-kaken 2020-7p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51660/files/ME-PR-YOSHIOKA-K-kaken 2020-7p.pdf"},"version_id":"4fdeb960-3c9c-4e9c-9c9f-8c5288eab606"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"膜動現象を制御するイノシトールリン脂質脱リン酸化酵素の肺発達・成熟における役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"膜動現象を制御するイノシトールリン脂質脱リン酸化酵素の肺発達・成熟における役割"},{"subitem_title":"Physiological roles of Phosphoinositide-specific phosphatase in lung development and maturation through regulating membrane trafficking","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-26"},"publish_date":"2021-04-26","publish_status":"0","recid":"51660","relation_version_is_last":true,"title":["膜動現象を制御するイノシトールリン脂質脱リン酸化酵素の肺発達・成熟における役割"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:05:31.371006+00:00"}