{"created":"2023-07-27T06:55:35.780254+00:00","id":51663,"links":{},"metadata":{"_buckets":{"deposit":"2718181f-4ee8-4847-9f43-81a7694de3b1"},"_deposit":{"created_by":18,"id":"51663","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51663"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051663","sets":["2812:2813:3929"]},"author_link":["103","69349"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-04-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"9p.","bibliographicVolumeNumber":"2018-06-29 - 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 挑戦的研究(萌芽) 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"哺乳類での研究で癌を助ける免疫細胞の存在がわかり、それは腫瘍随伴免疫細胞とよばれる。本研究ではショウジョウバエにそのような免疫細胞が存在するかどうかを検証した。その存在が明らかになれば、遺伝学を適用して腫瘍随伴免疫細胞の発生や機能に関わる遺伝子の包括的な同定が可能になる。まず、癌の有り無しの幼虫で免疫細胞の分布を調べたが、大きな違いはなかった。次に、免疫細胞の貪食活性を阻害した時の発癌程度を調べたが、期待の逆に増大がみられた。最後に、免疫細胞における遺伝子発現を調べると、癌の誘発で大きく変化することがわかった。その変化は免疫細胞の働きを低下させる方向であり、腫瘍随伴免疫細胞の存在が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Some types of immune cells in mammals help cancer cells and are called tumor-associated immune cells. In the present study, we verified the possible existence of such immune cells in Drosophila. If the answer is positive, studying tumor-associated immune cells with the aid of genetic approach is made possible.\nEstablishing a Drosophila model of cancer, we first examined the distribution of hemocytes in the vicinity of cancer cells, but this was not the case. We next examined the effects of inhibition of phagocytic activities of immune cells on cancer development, but the data showed an increase, not decrease, of the incident of cancer. Finally, we determined the pattern of gene expression in immune cells isolated from cancer-bearing and normal Drosophila. We found a clear difference in mRNA repertoire between the two groups. This change was toward a decline of immune cells’ activity. Collectively, our study suggests the presence of tumor-associated immune cells in Drosophila.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18K19395, 研究期間(年度):2018-06-29 - 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「ショウジョウバエを用いた腫瘍随伴免疫細胞の比較免疫学的研究」研究成果報告書　課題番号18K19395\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K19395/18K19395seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057966","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40172358"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40172358","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K19395/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K19395/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K19395/18K19395seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18K19395/18K19395seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-26"}],"displaytype":"detail","filename":"PH-PR-NAKANISHI-Y-kaken 2020-9p.pdf","filesize":[{"value":"938.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-NAKANISHI-Y-kaken 2020-9p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51663/files/PH-PR-NAKANISHI-Y-kaken 2020-9p.pdf"},"version_id":"8a2cd61f-1a28-4b69-a34f-adb94ec66be1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ショウジョウバエを用いた腫瘍随伴免疫細胞の比較免疫学的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ショウジョウバエを用いた腫瘍随伴免疫細胞の比較免疫学的研究"},{"subitem_title":"Comparative immunological research on tumor-associated immune cells using Drosophila","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-26"},"publish_date":"2021-04-26","publish_status":"0","recid":"51663","relation_version_is_last":true,"title":["ショウジョウバエを用いた腫瘍随伴免疫細胞の比較免疫学的研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:05:36.523104+00:00"}