{"created":"2023-07-27T06:55:36.010636+00:00","id":51668,"links":{},"metadata":{"_buckets":{"deposit":"251307ee-c0a1-4029-ac3f-56ce4460ac9c"},"_deposit":{"created_by":18,"id":"51668","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51668"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051668","sets":["2812:2813:2815"]},"author_link":["71987","3014"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-05-24","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2017-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"細胞分裂制御の破綻は、細胞のがん化やがんの悪性化の原因とも考えられており、正確な細胞分裂制御は極めて重要な機能であるが、未だ不明な点が多い。本研究では、がん細胞マーカーとしても知られる細胞内輸送制御因子JSAPの機能解析を通じ、細胞分裂制御機構の解明を試みた。その結果、JSAP欠損細胞では、細胞分裂期における染色体の分配異常、それに伴う染色体数の異常を示す細胞が多数観察された。さらに、細胞分裂制御因子の１つであるPLK1の細胞内局在性の異常も観察された。以上の結果から、JSAPはタンパク質の細胞内局在性を制御することにより、細胞分裂制御機構において重要な役割を持つことを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"The process of cell division is tightly regulated by cell cycle checkpoints. A failure of cell division is often associated with cellular transformation and tumorigenesis. Recent studies suggests that JSAP is a novel biomarker for various types of cancer. In this study, we investigated the effect of JSAP on cell division in mammalian cells. JSAP knockout caused lagging chromosomes and aneuploidy. Moreover, abnormal subcellular distribution of PLK1 is observed in JSAP knockout cells. Together, these findings suggest that JSAP plays a critical role in the regulation of chromosome segregation during mitotic cell division.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17K14991, 研究期間(年度):2017-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「JSAPによる染色体分配制御とその破綻がもたらすがんの発生・悪性化の分子機構」課題番号17K14991\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K14991/17K14991seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057971","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30761803"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30761803","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K14991/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K14991/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K14991/17K14991seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K14991/17K14991seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-26"}],"displaytype":"detail","filename":"CA-PR-NAKAZATO-R-kaken 2019-4p.pdf","filesize":[{"value":"264.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-NAKAZATO-R-kaken 2019-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51668/files/CA-PR-NAKAZATO-R-kaken 2019-4p.pdf"},"version_id":"a66c1de9-2d25-4a54-b717-fe412e67fd1f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"JSAPによる染色体分配制御とその破綻がもたらすがんの発生・悪性化の分子機構","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"JSAPによる染色体分配制御とその破綻がもたらすがんの発生・悪性化の分子機構"},{"subitem_title":"Functional analysis of JSAP in the regulation of chromosome segregation and cancer","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-26"},"publish_date":"2021-04-26","publish_status":"0","recid":"51668","relation_version_is_last":true,"title":["JSAPによる染色体分配制御とその破綻がもたらすがんの発生・悪性化の分子機構"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:34:45.645135+00:00"}