{"created":"2023-07-27T06:55:36.056790+00:00","id":51669,"links":{},"metadata":{"_buckets":{"deposit":"4e433c73-492b-4550-a022-57d78dd130b2"},"_deposit":{"created_by":18,"id":"51669","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51669"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051669","sets":["2812:2813:3929"]},"author_link":["25637"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-06-05","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"8p.","bibliographicVolumeNumber":"2017-04-01 - 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、マウスとヒトの胃がんオルガノイドを用いて、がん幹細胞の同定と悪性化機構の解明を試みた。また、得られた知見よりマウス生体内で胃がんに対する有効な治療法の探索を行った。上皮幹細胞マーカーLGR5遺伝子の発現に着目し解析を進め、LGR5陽性胃がん細胞ががん幹細胞である可能性を示唆する結果を得た。包括的な遺伝子発現解析により、これらの細胞の増殖・維持に関与する遺伝子群を明らかにした。胃がんオルガノイドをマウスの胃に同所移植することで、いくつかの遺伝子が実際に胃がん幹細胞の浸潤・転移を制御していることが明らかになった。さらに、胃がん幹細胞を選択的に除去できる薬剤候補を見つけた。","subitem_description_type":"Abstract"},{"subitem_description":"Our goal is to establish an effective treatment for gastric cancer. By using newly established mouse and human gastric cancer organoids, we tried to identify cancer-initiating cells and clarify the mechanism which induce their malignancy. Furthermore, based on knowledges, we searched for an effective treatment for gastric cancer in vivo. We proceeded our research with focusing on an epithelial stem cell marker, LGR5 and found that LGR5 positive gastric cancer cells could be the cancer-initiating cell. By a comprehensive gene expression analysis, we found a group of genes which could regulate proliferation and maintenance of cancer-initiating cells. We orthotopically transplanted genetically modified organoids into mouse stomach and found that some genes can regulate the metastatic ability of cancer-initiating cells. Furthermore, we found drug candidates which can selectively eliminate cancer-initiating cells.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17K07161, 研究期間(年度):2017-04-01 - 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「オルガノイドを用いた胃がん幹細胞の可視化と効果的な治療法の探索」研究成果報告書　課題番号17K07161\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K07161/17K07161seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057972","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60455368"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60455368","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K07161/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K07161/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K07161/17K07161seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K07161/17K07161seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-26"}],"displaytype":"detail","filename":"CA-PR-MURAKAMI-K-kaken 2020-8p.pdf","filesize":[{"value":"238.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-MURAKAMI-K-kaken 2020-8p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51669/files/CA-PR-MURAKAMI-K-kaken 2020-8p.pdf"},"version_id":"2c20cd0c-8762-4170-8224-a1a46d1100f8"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"オルガノイドを用いた胃がん幹細胞の可視化と効果的な治療法の探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"オルガノイドを用いた胃がん幹細胞の可視化と効果的な治療法の探索"},{"subitem_title":"Visualization of cancer-initiating cells and search for an effective treatment using gastric cancer organoids","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-26"},"publish_date":"2021-04-26","publish_status":"0","recid":"51669","relation_version_is_last":true,"title":["オルガノイドを用いた胃がん幹細胞の可視化と効果的な治療法の探索"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:06:19.542150+00:00"}