{"created":"2023-07-27T06:55:36.879369+00:00","id":51687,"links":{},"metadata":{"_buckets":{"deposit":"3af0dc23-63cd-44cc-965a-338fdebfd173"},"_deposit":{"created_by":18,"id":"51687","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51687"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051687","sets":["2812:2813:4014"]},"author_link":["84980","84979"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-06-07","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"7p.","bibliographicVolumeNumber":"2019-04-01 – 2021-03-31","bibliographic_titles":[{"bibliographic_title":"令和2(2020)年度 科学研究費補助金 若手研究 研究成果報告書"},{"bibliographic_title":"2020 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"予備実験より、高血圧症の発症機序にステロイド代謝物と腸内細菌叢の関与が疑われた。そこで我々は一般住民242名を対象に、腸内細菌叢の構成と高血圧有病率を比較し、Bifidobacterium属などの存在比の低い腸内細菌叢を持つ群は、低食塩摂取でも高食塩と同等の高血圧有病率であることを示した。特にB. bifidumやB. Breveとの関連が強い傾向にあり、IL-17などのサイトカインとの関連が強く、ステロイドメタボロミクス解析の結果、いくつかのミネラロコルチコイドとの関与が示唆された。さらなる食塩感受性高血圧発生機序を解明のためにメタゲノム解析や動物モデへの移植実験を追加予定である。","subitem_description_type":"Abstract"},{"subitem_description":"Hypertension causes stroke, heart disease, and kidney disease. Hypertension is classified into two groups: salt-sensitive hypertension, in which blood pressure improves with salt reduction, and salt-resistant hypertension, in which blood pressure does not. We compared the composition of the gut microbiota and the prevalence of hypertension in 242 general residents, and found that the prevalence of hypertension in the group of patients with gut microbiota low in Bifidobacterium was similar to that in the group with high salt intake, even with low salt intake. In particular, there was a strong tendency to be associated with B. bifidum and B. breve, and steroid metabolomics analysis suggested involvement with some mineralocorticoids. To further elucidate the mechanism of salt-sensitive hypertension, we plan to conduct additional metagenomic analysis and transplantation experiments into animal models.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19K17956, 研究期間(年度):2019-04-01 – 2021-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「ステロイドメタボロミクス解析による生活習慣病発症バイオマーカーの探索的研究」研究成果報告書　課題番号19K17956\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19K17956/19K17956seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院内分泌・代謝内科","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057990","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30801584"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30801584","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K17956/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K17956/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19K17956/19K17956seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19K17956/19K17956seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-18"}],"displaytype":"detail","filename":"GS-PR-KARASHIMA-S-kaken 2021-7p.pdf","filesize":[{"value":"361.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"GS-PR-KARASHIMA-S-kaken 2021-7p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51687/files/GS-PR-KARASHIMA-S-kaken 2021-7p.pdf"},"version_id":"9c4993f2-a266-46f2-9ed9-1a302d38a0c0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ステロイドメタボロミクス解析による生活習慣病発症バイオマーカーの探索的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ステロイドメタボロミクス解析による生活習慣病発症バイオマーカーの探索的研究"},{"subitem_title":"Exploratory study of biomarkers for the development of lifestyle-related diseases by steroid metabolomics analysis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["4014"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-18"},"publish_date":"2022-02-18","publish_status":"0","recid":"51687","relation_version_is_last":true,"title":["ステロイドメタボロミクス解析による生活習慣病発症バイオマーカーの探索的研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:50:08.718358+00:00"}