{"created":"2023-07-27T06:55:36.971466+00:00","id":51691,"links":{},"metadata":{"_buckets":{"deposit":"e54e33e4-6ad1-4318-8af3-97afbc9afdd9"},"_deposit":{"created_by":18,"id":"51691","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"51691"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00051691","sets":["2812:2813:3929"]},"author_link":["1880","85162"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-04-30","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"12p.","bibliographicVolumeNumber":"2017-04-01 - 2020-03-31","bibliographic_titles":[{"bibliographic_title":"令和1(2019)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2019 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"心筋虚血再灌流ラットにおける梗塞後の早期炎症性変化と慢性期左室リモデリングの関連において治療的介入としてのpost-conditioning(PC)と直接的な抗炎症薬としてのコルヒチン治療の影響を検討した。 マクロファージ浸潤を反映して集積するC-14メチオニン集積はPCにより梗塞3日後には低下しなかったがその後の低下が促進された。一方、コルヒチン投与では3日後から全経過においてメチオニン集積は抑制された。いずれにおいても2か月後の左室リモデリングは抑制され、メチオニンイメージングにより炎症性変化に対する治療効果判定が可能で、左室リモデリング抑制予測の可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Serial C-14-methionine imaging, that mainly reflects macrophage infiltration, after 30min myocardial ischemia and reperfusion and subsequent left ventricular remodeling at 2 months was investigated under condition with post-conditioning and colchicine treatment. In rats with post-conditioning, peaked methionine uptake at day 3 was not suppressed compared with control rats, however, subsequent resolution of methionine uptake at 1 to 2 weeks was accelerated and ventricular remodeling at 2 months was attenuated. In rats treated with colchicine during 1 to 6 day after infarction, peaked methionine uptake at day 3 and subsequent 1 to 2 weeks was all suppressed and ventricular remodeling at 2 months was attenuated. As an inflammatory imaging, C-14-methionine imaging could be used to monitor the effect of treatments on post-infarction inflammation and to predict left ventricular remodeling at chronic phase.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17K10435, 研究期間(年度):2017-04-01 - 2020-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「心筋梗塞後の病態変化と左室リモデリング予測に関する継時的生体分子イメージング研究」研究成果報告書　課題番号17K10435\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K10435/17K10435seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00057994","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10251927"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10251927","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K10435/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K10435/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K10435/17K10435seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K10435/17K10435seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-26"}],"displaytype":"detail","filename":"ME-PR-TAKI-J-kaken 2020-12p.pdf","filesize":[{"value":"99.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-TAKI-J-kaken 2020-12p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/51691/files/ME-PR-TAKI-J-kaken 2020-12p.pdf"},"version_id":"8c54b173-62d4-4a4f-a4ee-12f1bc8370bd"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"心筋梗塞後の病態変化と左室リモデリング予測に関する継時的生体分子イメージング研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"心筋梗塞後の病態変化と左室リモデリング予測に関する継時的生体分子イメージング研究"},{"subitem_title":"Serial molecular imaging for the prediction of the left ventricular remodeling after myocardial infarction","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["3929"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-26"},"publish_date":"2021-04-26","publish_status":"0","recid":"51691","relation_version_is_last":true,"title":["心筋梗塞後の病態変化と左室リモデリング予測に関する継時的生体分子イメージング研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:06:28.993005+00:00"}